Thursday 7 May, 2026
Background & Objectives: Selective aldosterone synthase inhibitors (ASi), such as vicadrostat, are being developed to prevent or slow the progression…
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MODEL-INFORMED DOSAGE SELECTION FOR GOCATAMIG, A TRI-SPECIFIC, HALF-LIFE–EXTENDED DLL3-DIRECTED T-CELL ENGAGER IN PATIENTS WITH SMALL CELL LUNG CANCER AND OTHER NEUROENDOCRINE CANCERS
Thursday 7 May, 2026
Objectives: Gocatamig (MK-6070), is a DLL3-targeting T-cell engager that redirects T cells to kill DLL3-expressing cancer cells. Gocatamig has shown…
Read moreVALIDATION OF THE ACATPLUS MECHANISTIC COLONIC ABSORPTION MODEL IN GASTROPLUS USING A GUT-TARGETED COMPOUND
Thursday 7 May, 2026
Introduction: Gut-targeted compounds present an opportunity to locally affect the gastrointestinal (GI) tract while simultaneously benefitting from a more desirable…
Read moreIntegrated Pharmacokinetics–Receptor Occupancy Modeling of EVER001 to Guide Clinical Efficacious Dose Projection for Primary Membranous Nephropathy
Thursday 7 May, 2026
Introduction: Primary membranous nephropathy (pMN) is an autoimmune disease caused by specific autoantibodies produced by B cells that attack the…
Read moreExposure–response evaluation and simulation studies of IMC-001 using a model incorporating FcRn recycling
Thursday 7 May, 2026
Objectives IMC-001 is a novel PD-L1 antibody that is a fully human anti-PD-L1 IgG1 monoclonal antibody which has shown promising…
Read moreA logistic regression framework for predicting time‑varying vaccine efficacy using longitudinal immunogenicity data: a dengue vaccine case study
Thursday 7 May, 2026
Objectives: The durability of vaccine-induced protection and its variability across different demographic groups are key questions in vaccine development. Traditional…
Read moreASSESSMENT OF PIPERACILLIN–TAZOBACTAM VARIABILITY IN OBESITY THROUGH POPULATION PHARMACOKINETIC MODELING
Thursday 7 May, 2026
Introduction/Objectives: Over the past decades, the prevalence of obesity has risen at an alarming rate worldwide [1]. Obesity is commonly…
Read moreAI-DRIVEN EARLY DETECTION OF COLORECTAL CANCER USING LONGITUDINAL AND MULTIMODAL ELECTRONIC HEALTH RECORDS IN SWEDISH PRIMARY HEALTH CARE
Thursday 7 May, 2026
Introduction: Colorectal cancer (CRC) remains a leading cause of cancer incidence and mortality worldwide[1]. In Sweden, it ranks as the…
Read moreUsing deconvolution to support the development of an abemaciclib parent-metabolite joint pharmacokinetic model
Thursday 7 May, 2026
Introduction: Abemaciclib is an orally administered drug targeting the cyclin-dependent kinase 4 and 6 (CDK4/6), responsible for tumour growth. It…
Read moreBayesian population PK estimation of linear PK parameters of monoclonal AB with reusable priors for downstream applications.
Thursday 7 May, 2026
Introduction: Monoclonal antibodies (mABs) typically show linear PK which are consistent for the class, under target-absent conditions. It would be…
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