Introduction/Objectives Chemotherapy-induced neutropenia remains a significant dose-limiting toxicity, and granulocyte colony-stimulating factor (G-CSF) prophylaxis represents a cornerstone of supportive care…
Read moreObjectives: Can pharmacometric (PMX) modeling support individualized dose optimization in pediatric thyroid diseases, where inter-individual variability, developmental changes, and heterogeneous…
Read moreINTRODUCTION Clinical reporting of Tables, Figures and Listings (TFLs) is often time-consuming and error-prone due to repetitive post-processing and formatting…
Read moreObjectives: Autosomal Recessive Cerebellar Ataxias (ARCAs) are ultra-rare, progressive neurodegenerative disorders that primarily affect the cerebellum but also cause multi-systemic…
Read moreObjectives: Chimeric antigen receptor (CAR)-T cell therapies display pharmacokinetics (PK) characterized by distribution, expansion, and elimination. These PK are often…
Read moreThis tutorial aims to expound on methodological aspects typically encountered when performing model-based meta-analyses (MBMA). This includes how to handle…
Read moreIntroduction: Tebipenem pivoxil (TBP-PI) is an orally bioavailable carbapenem prodrug that is rapidly converted in vivo to the active moiety,…
Read moreObjectives BTZ-043, a drug candidate currently under investigation for treatment of tuberculosis (TB), inhibits cell wall synthesis of mycobacteria by…
Read moreIntroduction: The assessment of proarrhythmic risk via the analysis of QT interval prolongation is an integral part of drug development. Since…
Read moreObjectives: Central nervous system (CNS) infections such as meningitis, ventriculitis, and encephalitis occur across physiologically distinct compartments where antibiotic distribution…
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