Thursday 16 October, 2025
Objectives: Tisotumab vedotin (TV), a tissue factor-directed antibody-drug conjugate (ADC), is approved in the United States at a dose of 2.0…
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In silico trials platform for exploration of trial design space in atopic dermatitis
Thursday 16 October, 2025
Objectives: Atopic dermatitis (AD) clinical trials are stymied by a complex pathophysiology characterized by a wide spectrum of endotypes and…
Read moreGeneration of a virtual population for a multi-strain model of natural and vaccinal immunization against influenza
Thursday 16 October, 2025
Objectives: The generation of a Virtual Population (VP) is the one of the last steps of a QSP model calibration…
Read moreTranslational physiologically based pharmacokinetic modeling to predict human pulmonary kinetics after inhalation
Thursday 16 October, 2025
Objectives: Oral inhalation is an attractive approach for drug delivery, especially when targeting respiratory diseases. Inhalation provides a rapid onset…
Read moreAutomated QSP model order reduction combining multiple state-level reduction approaches
Thursday 16 October, 2025
Objectives: Quantitative systems pharmacology (QSP) models are useful tools for drug target identification and extrapolation. However, their large size can…
Read moreModel-based evaluation of predictive markers of response to adalimumab in juvenile idiopathic arthritis
Thursday 16 October, 2025
Introduction: Juvenile Idiopathic Arthritis (JIA) is a group of heterogeneous idiopathic inflammatory arthritis characterised by childhood-onset [1]. The ability of…
Read moreA model-based algorithm for mycophenolate dose adjustment in paediatric transplantation patients
Thursday 16 October, 2025
Introduction: The immunosuppressant effect of mycophenolate sodium is determined by mycophenolic acid (MPA), which is the active component released in…
Read moreVirtual population analysis of a Quantitative Systems Pharmacology (QSP) model of atopic dermatitis (AtD) to evaluate AtD treatments
Thursday 16 October, 2025
Introduction: Atopic dermatitis (AtD) is a chronic inflammatory skin condition characterized by eczematous lesions and intense itch [1]. The exact cause…
Read moreHuman effective dose prediction of analgesic drug using translational PK-PD modeling
Thursday 16 October, 2025
Objective: Translational PK–PD modeling is aimed to predict exposure-response relationships in human based on preclinical data[1]. As such translational research…
Read moreModel informed dosage regimen optimization of anti-CD47 antibody using target-mediated drug disposition model.
Thursday 16 October, 2025
Objectives: Target-mediated drug disposition (TMDD) model is used to describe a nonlinear pharmacokinetics (PK) phenomenon that is caused by high-affinity…
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