Thursday 16 October, 2025
Objectives: Nowadays, with overall improvement in medical standards, demand of individualized pharmaceutical intervention is on growing. On the other hand,…
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Comparative Study of Target Mediated Drug Disposition Approximation Methods Based on Validity Conditions: Application to Clinical Trial Studies
Thursday 16 October, 2025
Objectives: Target-Mediated Drug Disposition (TMDD) is a phenomenon that occurs when a potent and specific drug binds to the target site…
Read moreProteolysis-Targeting Chimera (PROTAC) Design using Integrated Artificial Intelligence (AI) and Quantitative Systems Pharmacology (QSP) Model.
Thursday 16 October, 2025
Objectives: Proteolysis-Targeting Chimera (PROTAC) is new type of bifunctional engineered molecule what it allows to bring the target protein and…
Read moreA simulation-based sample size analysis of a joint model of longitudinal and survival data for patients with glioma
Thursday 16 October, 2025
Introduction Patients with recurrent high-grade glioma (rHGG) have poor prognosis with median progression-free survival (PFS) <6 months, and median overall…
Read moreNon-linear autoregressive exogenous modelling to predict individual haematotoxicity during chemotherapy
Thursday 16 October, 2025
Objectives: Cytotoxic cancer therapies frequently result in severe haematotoxic side-effects. Predicting a patient’s haematologic response to treatment is of high…
Read moreCombining biological knowledge and machine learning for predicting dynamics of haematotoxcity after chemotherapy: a comparative analysis
Thursday 16 October, 2025
Objectives: Cytotoxic treatment in cancer therapy is frequently accompanied by dose-limiting haematotoxic side-effects. Predicting an individual’s risk holds significant clinical…
Read moreImpact of censoring on non-linear effect modeling of aggregate-level survival data
Thursday 16 October, 2025
Introduction: Model-based meta-analysis (MBMA) applies statistical models to aggregate-level trial data to compare the treatment effects across studies using data…
Read moreA model-based meta-analysis of immune-related adverse events during immune checkpoint inhibitors treatment for NSCLC
Thursday 16 October, 2025
Introduction: Immune checkpoint inhibitors (ICIs) have become a landmark therapy over recent years benefitting from their remarkable clinical efficacy in…
Read morePredicting Motor function scores using uHex4 biomarker effect in Pompe disease
Thursday 16 October, 2025
Objectives: Text regarding objectives. Methods: Text regarding methods. Results: Text regarding results. Conclusions: Text regarding conclusions. References: [1] Text for…
Read moreEffect brain irradiation with X-ray/Proton beam on circulating immune cell in rodents: A longitudinal modeling approach
Thursday 16 October, 2025
Objectives Leucocyte can influence tumor growth and response to radiotherapy, one of the standard therapies in brain tumors. While radiation-induced…
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