Thursday 16 October, 2025
BACKGROUND Peritonitis is a major complication of peritoneal dialysis (PD)[1]. Despite recent progress in PD product safety, studies still showed…
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Population pharmacokinetics and pharmacodynamics of eravacycline against pulmonary infections
Thursday 16 October, 2025
Introduction: Eravacycline is a broad-spectrum fluorocycline approved to treat complicated intra-abdominal infections. In lung-infected animal models, it was effective against…
Read moreMeta-analysis of parameter estimates of non-linear mixed effect models using Approximate Bayesian Computation: application to population pharmacokinetics
Thursday 16 October, 2025
Introduction: Non-Linear Mixed Effect Models (NLMEM) are a gold standard tool to analyze pharmacokinetic (PK) data. Generally, numerous population PK…
Read morePopulation pharmacokinetic analysis of isoniazid in plasma and cerebrospinal fluid from adults with HIV-associated tuberculosis meningitis
Thursday 16 October, 2025
Objectives: Tuberculosis Meningitis (TBM) represents the most severe and incapacitating manifestation of infection by Mycobacterium tuberculosis, especially among individuals with…
Read moreStructural model development with compartmental pharmacokinetic models for a range of small molecule subcutaneous data
Thursday 16 October, 2025
Objectives: The development of pharmacokinetic (PK) and pharmacodynamic (PD) models demands considerable time from highly skilled scientists, and the need for…
Read moreDevelopment of an R Shiny application to aid pre-clinical development of immune-oncology compounds at Genmab
Thursday 16 October, 2025
Objectives: Monoclonal antibodies (mAbs) have been modified to promote binding affinity, half-life in circulation and effectiveness towards targets, especially in…
Read morePopulation Pharmacokinetic Modelling of Twice Daily 50mg Dolutegravir in Children with Tuberculosis and HIV during Rifampicin Co-administration
Thursday 16 October, 2025
Introduction: The World Health Organization (WHO) recommends a dolutegravir-based regimen for first-line antiretroviral treatment (ART), with ART initiated during tuberculosis…
Read moreQuantitative approaches of time-varying weight gain effects of antipsychotic drugs for Schizophrenia by model based meta-analysis.
Thursday 16 October, 2025
Objectives: Despite weight gain is one of the most important adverse drug effect(ADR) of antipsychotics[1], the quantitative approach was restricted…
Read moreIndividualized Tacrolimus dosing in pediatric kidney transplantation: identification of new genomic, proteomic and metabolomic biomarkers and PhysPK® development of PBPK-based predictive models, simulations and applications in different phamacogenomic subpopulations.
Thursday 16 October, 2025
Objectives: Tacrolimus (TCR) is the primary immunosuppressive (IS) drug used in pediatric kidney transplantation. As other IS, TCR presents a high…
Read morePotential of Tacrolimus CYP3A5 genotyping to predict phenotype (C0/Dose/Weight ratio) and applicability of PBPK modelling to improve dosing strategies in paediatric kidney transplant recipients
Thursday 16 October, 2025
Objectives: Tacrolimus (TCR), the main immunosuppressive in kidney transplantation to prevent drug toxicity and graft rejection, has a narrow therapeutic…
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