Thursday 16 October, 2025
Introduction Antimicrobial resistance is a rapidly spreading threat to global public health. Efficient drug development is required to increase the…
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Exposure-Response Analysis of Centanafadine Sustained Release Tablets in Adults with Attention-Deficit/Hyperactivity Disorder
Thursday 16 October, 2025
Objectives: Centanafadine is a small-molecule with inhibitory activity at norepinephrine, dopamine, and serotonin reuptake transporters and is under development for…
Read moreLocal TMDD of large molecules in tissue interstitial space
Thursday 16 October, 2025
Introduction: Large molecule drugs, including monoclonal antibodies and antibody-drug conjugates, bind with high affinity and specificity to their targets and…
Read moreSmall molecule drug absorption in inflammatory bowel disease and current implementation in PBPK models.
Thursday 16 October, 2025
Introduction: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestinal mucosa, with predominant localization in the colon…
Read moreA streamlined, semi-automated workflow allows quick and efficient QTc and other ECG intervals modeling assessment, saving time and cost.
Thursday 16 October, 2025
Introduction All drugs with systemic bioavailability need assessment of the QT interval which represents ventricular repolarization activity of the heart…
Read morePhysiologically based pharmacokinetic modeling and simulation of a promising novel antiplatelet drug vicagrel and its metabolites
Thursday 16 October, 2025
Introduction: Vicagrel, an innovative antiplatelet medication originating from Jiangsu Vcare PharmaTech Co. Ltd., China, is aimed at addressing clopidogrel resistance…
Read moreUnlocking efficiency in dose selection based on pharmacokinetic-pharmacodynamic modeling of tumor size data: Insights from Clinical Trial Simulations
Thursday 16 October, 2025
Objectives: Dose optimization is a critical objective of early clinical development of oncology drugs. The value of longitudinal tumor size…
Read moreA mechanism-based pharmacokinetic/pharmacodynamic model for iron-regulated hematopoietic stem and progenitor cells commitment towards erythroid and megakaryocyte lineages
Thursday 16 October, 2025
Introduction: Iron is an essential element for almost all living organisms. Iron deficiency causes anemia, which is associated with reduced…
Read moreCumulative exposure to infliximab during induction therapy predict remission in patients with Crohn’s disease and ulcerative colitis
Thursday 16 October, 2025
Objectives:Infliximab, an anti-tumor necrosis factor monoclonal antibody, has revolutionized the pharmacological management of inflammatory bowel diseases (IBDs), but non-response to…
Read moreA Novel Approach Using Pharmacometrics/Pharmacoeconomic (PMPE) Model for Cost-effectiveness Analysis of Tacrolimus-Diltiazem Combination in Liver Transplant Patients: Evidence from Real-world Clinical Data
Thursday 16 October, 2025
Introduction: Tacrolimus (TAC) is a typical immunosuppressant that is metabolized by the CYP3A4/CYP3A5 enzyme[1], commonly used in liver transplants to…
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