Thursday 16 October, 2025
Introduction: Pediatric patients undergoing continuous kidney replacement therapy (CKRT) in intensive care units (ICUs) may suffer from infections caused by…
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A quantitative system toxicology model of thyroid hormones for assessment of species differences in thyroid toxicity
Thursday 16 October, 2025
Objectives: The current practice of medicines or chemicals toxicity assessment still relies on extensive preclinical studies. The assessment of potential endocrine…
Read morePharmacokinetic–pharmacodynamic modeling and treatment simulation of maintenance therapy for childhood acute lymphoblastic leukemia
Thursday 16 October, 2025
Introduction: Acute lymphoblastic leukemia (ALL) is one of the most common pediatric malignancies [1] and is treated with initial high-dose…
Read moreBridging the gap between secondary pharmacology and hemodynamics findings via Quantitative Systems modelling
Thursday 16 October, 2025
Objectives: Pharmaceutical companies routinely screen compounds in vitro and in vivo to understand hemodynamics related safety risks. Our current model…
Read moreUnderstanding Population Heterogeneity in Vaccine-induced Immunity: A Mechanistic Model for Immune Fingerprinting
Thursday 16 October, 2025
Objectives: : Vaccines are pivotal in combating infectious diseases, saving millions of lives worldwide and vastly improving public health. Despite their…
Read moreExternal evaluation of a population pharmacokinetic (POP-PK) model of Cabotegravir HIV-1-infected patients treated with long-acting Cabotegravir/Rilpivirine (LA CAB-RPV)
Thursday 16 October, 2025
Objectives: Cabotegravir is a potent integrase strand transfer inhibitor recently approved as a long-acting (LA) intramuscular (IM) injection in combination…
Read moreDevelopment of a pharmacokinetic-pharmacodynamic model to describe blood hepcidin levels in patients with myelofibrosis and assess target engagement of zilurgisertib, an ALK2 inhibitor
Thursday 16 October, 2025
Introduction: Anaemia is a predominant feature of myelofibrosis (MF), a type of myeloproliferative neoplasm, and is associated with poor prognosis…
Read moreModel-informed dose optimization of mycophenolic acid in pediatric renal transplant patients
Thursday 16 October, 2025
Introduction: Mycophenolic acid (MPA), the active compound of the prodrug mycophenolate mofetil (MMF), is a pharmacotherapeutic cornerstone to prevent allograft…
Read moreInfluential factors on the type I error rate in pharmacometrics models using individual model averaging or standard approach
Thursday 16 October, 2025
Objectives: When assessing treatment effects in clinical studies by pharmacometrics modelling, type 1 error (T1) may be inflated in presence…
Read moreMechanisms of ART-free virus control of SHIV with AAV gene therapy delivery of eCD4Ig
Thursday 16 October, 2025
Introduction: The human immunodeficiency virus (HIV) is a retrovirus infecting primarily CD4 T cells. Antiretroviral therapy (ART) suppresses plasma HIV…
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