Thursday 16 October, 2025
Objectives: Despite making up more than 60% of the world’s population, Asian genomes are under-characterized. A large-scale whole genome sequencing…
Read moreAbstracts
Discovering Intrinsic PK/PD Models Using Physics Informed Neural Networks
Thursday 16 October, 2025
Introduction: Pharmacokinetic-pharmacodynamic (PK/PD) models employ ordinary differential equations (ODEs) for describing the relationship between dose, concentration, intensity, and response duration…
Read moreMechanistic modelling of tumor kinetics coupled with biomarker dynamics for survival prediction in non-small cell lung cancer patients
Thursday 16 October, 2025
Objectives: Simple blood markers derived from routine hematology or biochemistry have been reported to be prognostic factors of overall survival (OS) in cancer patients [1,2]. However, most studies only use baseline (BSL) values. The only longitudinal biomarker that has been extensively used and modeled to date is tumor size kinetics…
Read moreRelative impact of CYP2D6 phenotype, physiological changes and hepatic extraction ratio on drug exposure during pregnancy
Thursday 16 October, 2025
Title: Relative impact of CYP2D6 phenotype, physiological changes and hepatic extraction ratio on drug exposure during pregnancy Author: Karen Rowland Yeo1,…
Read moreA Minimal PBPK Model to Predict Biodistribution of Silica Nanoparticles in Mice
Thursday 16 October, 2025
Introduction: Due to their superior drug loading capacity, mechanical stability, and stimuli-responsive release profile for controlled drug delivery, silica nanoparticles…
Read moreEvaluating empirical dose-response relationships and dosing strategies of bacteriophage therapy using a mechanism-based modeling approach
Thursday 16 October, 2025
Background and objectives: Bacteriophages, or phages, are viruses capable of infecting and replicating within bacterial cells, and ultimately lysing them….
Read morePopulation pharmacokinetics of ticagrelor and its active metabolite in a real-life hospitalized population
Thursday 16 October, 2025
Objectives: Ticagrelor (reversible P2Y12-receptor antagonist) in combination with aspirin is a well-established treatment of acute coronary syndromes (ACS). Approximately 30-40%…
Read moreHow should target-mediated drug disposition model be used for predicting receptor occupancy?
Thursday 16 October, 2025
Objectives: Assessing target engagement is important for understanding drug action and selecting dosing regimens. The binding of the drug to…
Read moreDevelopment of a multi-endpoint mechanistic pharmacokinetic-pharmacodynamic model describing CD40 antagonism in autoimmune diseases.
Thursday 16 October, 2025
Introduction: CD40 is a transmembrane protein expressed by several immune cells [1] and plays a central role in a variety…
Read moreA Nonlinear Mixed Effect model of the LNA-i-miR-221 kinetics in rats for predicting key parameters of human kinetics via allometric scaling
Thursday 16 October, 2025
Objectives: MicroRNAs (miRs) are small, noncoding regions of single-stranded RNA that have recently garnered major attention as key regulators of…
Read more