Thursday 16 October, 2025
Introduction: Exposure-response (E-R) modeling plays an important role in model-informed drug development, especially in dose selection. A key step in…
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Modelling and simulation of the effect of a permeability enhancer on the absorption of a poorly permeable compound
Thursday 16 October, 2025
Introduction: Compound A is highly soluble at physiological pH, highly bound to proteins (%PPB >99.9%) and has poor permeability (Caco-2…
Read moreStochastic Gate Neural Networks for Automatic Covariate Selection in Pharmacometrics Population Modeling
Thursday 16 October, 2025
Introduction: Population pharmacokinetic (PK) models describe the behavior of drugs in the body and are usually constructed within a nonlinear…
Read moreUtility of Physiologically-based Pharmacokinetic Model to Predict Inter-Antibody Variability in Monoclonal Antibody Pharmacokinetics
Thursday 16 October, 2025
Objectives: In this investigation, we test the hypothesis that within a PBPK framework, experimentally determined in vitro physiochemical assay metrics could…
Read morePKPD model evaluating the ideal interplay between the PK and mechanism of activation of conditionally activated molecules
Thursday 16 October, 2025
Objectives: Conditionally activated molecules are designed to deliver a targeted therapy or reduce the off-tumor activity by exploiting specific properties…
Read moreExploration of CPRD and Yellow Card real-world data to support efficacy and safety targets for levonorgestrel contraceptives.
Thursday 16 October, 2025
Introduction: Failure of contraception is uncommon but inconsistent use is a significant cause of unintended pregnancies. Short-acting contraceptives rely on…
Read morePredicting the effect of postpartum changes in breastmilk composition on the partitioning of anti-malarial medications
Thursday 16 October, 2025
Introduction: Breastmilk provides the optimum nutrition and immune protection for infants and the World Health Organisation therefore recommends exclusive breastfeeding…
Read morePopulation Pharmacokinetic of ketamine and norketamine in pediatric subjects during analgosedation
Thursday 16 October, 2025
Objectives: Ketamine (KET) is a potent agent for pediatric procedural sedation and anesthesia. Yet ketamine is burdened by adverse events (ADEs),…
Read moreIdentifying SHAP’s added value to PK covariate modeling on a small dataset
Thursday 16 October, 2025
Introduction: Covariate model building can be the most time-consuming step of popPK modeling. To reduce this time required, several machine…
Read morePopulation Pharmacokinetic/Pharmacodynamic Modelling of Cytokine Releasing Syndrome (CRS) Events during T cell Engager Therapy
Thursday 16 October, 2025
Objectives: T cell engager therapies can direct T cells to attack tumor cells, thereby creating an immunological synapse that results…
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