Thursday 7 May, 2026
Introduction/Objectives: Olanzapine is a second-generation antipsychotic drug for the treatment of schizophrenia. Oral administration requires daily dosing, often limiting long-term…
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Use the AUC and discard Cmax in exposure-response analysis
Thursday 7 May, 2026
Introduction Exposure-response (ER) analyses of repeatedly administered drugs often rely on the use of an exposure metric at steady-state: the…
Read moreNORMALIZATION TO BODY WEIGHT IN PAEDIATRIC PHARMACOKINETICS: IMPACT ON CLEARANCE SCALING
Thursday 7 May, 2026
Introduction/Objectives: Clearance (CL) is a primary determinant of systemic exposure and plays a central role in dose selection and optimization….
Read morePhysiologically Based Pharmacokinetic Modeling of Rilpivirine to Support Trimester-Specific Dose Optimization in Pregnant Women Living With HIV
Thursday 7 May, 2026
Objectives: Rilpivirine (RPV) systemic exposure decreases by approximately 30-50% during the second and third trimesters of pregnancy, raising concerns about…
Read moreCross-tissue evaluation of a proteomics-derived ppm-to-nM conversion for target expression inputs to antibody PBPK/TMDD models
Thursday 7 May, 2026
Introduction: In antibody therapy, accurate prediction of first-in-human dose often requires accounting for target-mediated drug disposition (TMDD), for which PBPK…
Read morePharmpy: an open-source software package for pharmacometric modeling and scripting
Thursday 7 May, 2026
Pharmpy [1] is an open-source software package for pharmacometric modeling intended for scripting of pharmacometric workflows and automated model development….
Read moreExtending the open source saemix package to multiple responses and complex models
Thursday 7 May, 2026
Introduction: Quantifying the sources of individual variability in drug concentrations through non-linear mixed effect models (NLMEM) has proven instrumental in…
Read morePopulation pharmacokinetics–driven optimization of CFU-reduction study design for boosted ethionamide combinations in mice
Thursday 7 May, 2026
Objectives: Ethionamide (Eto) is used in combination regimens for pulmonary multidrug-resistant tuberculosis (MDR-TB), with known poor tolerability. Alpibectir is currently…
Read moreA Pharmacokinetic-Based Decision Tree to Guide Methods Selection for Safety Evaluation of Infant Systemic Exposure through Human Milk
Thursday 7 May, 2026
Introduction/Objectives: More than 50% of women take at least one medication during lactation. However, 54% of the drugs in the…
Read moreUNDERSTANDING THE ORAL BIOAVAILABILITY OF VORICONAZOLE: A STEP TOWARDS A COMPREHENSIVE CYP2C19‑ AND CYP3A4‑MEDIATED DRUG‑DRUG‑GENE INTERACTION NETWORK
Thursday 7 May, 2026
Voriconazole (VRC) is a second-generation triazole antifungal with broad-spectrum activity, and remains a cornerstone of antifungal therapy, particularly for invasive…
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