Thursday 7 May, 2026
Introductions: Approximately 15-20% of breast cancers overexpress human epidermal growth factor receptor 2 (HER2), a molecular subtype associated with poor…
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Quantitative systems pharmacology model for follicle development and oocyte retrieval during ovarian stimulation
Thursday 7 May, 2026
Introduction: Based on 48 years of improving in-vitro fertilisation (IVF) treatment protocols, there is today a deep mechanistic understanding of…
Read moreACTIVE LEARNING WITH BAYESIAN OPTIMIZATION FOR EFFICIENT VIRTUAL POPULATION GENERATION USING QUANTITATIVE SYSTEMS PHARMACOLOGY MODELS
Thursday 7 May, 2026
Objectives: Virtual population generation requires identifying feasible parameter combinations that produce physiologically realistic model outputs. Random sampling scales poorly with…
Read moreTranslational modelling of pembrolizumab reveals a knowledge gap in immune checkpoint inhibitor dose development
Thursday 7 May, 2026
Background Optimal dosing of immune checkpoint inhibitors (ICI) like programmed death-1 (PD-1) inhibitors remains uncertain, as dose–response relationships are not…
Read moreDOES THEORETICAL TARGET ATTAINMENT REFLECT REAL-WORLD TARGET ACHIEVEMENT? AN EVALUATION IN INTENSIVE CARE UNIT PATIENTS RECEIVING PIPERACILLIN AS CONTINUOUS INFUSION
Thursday 7 May, 2026
Introduction: Model-informed precision dosing (MIPD) aims to individualise antimicrobial therapy using pharmacokinetic models. These models need to be evaluated prior…
Read moreHost Immunity as a Bidirectional Regulator of Phage Therapy: A Mechanism-Based PKPD Modeling Approach
Thursday 7 May, 2026
Objectives Bacteriophage therapy in immunocompetent hosts is governed not only by phage replication and bacterial dynamics, but also by host…
Read moreSimulation-based guideline implementation of weight-banded dosing strategies for childhood leprosy
Thursday 7 May, 2026
Introduction Leprosy remains an important cause of morbidity among children in vulnerable settings. Treatment consists of a 6- to 12-month…
Read moreSensitivity analysis and calibration for a computationally expensive PBPK model: a case study for the PERSERIS™ in-situ forming PLGA-based implant
Thursday 7 May, 2026
Introduction: Sensitivity Analysis (SA) describes a class of methods for studying the relationships between the inputs and outputs of a…
Read moreA Modular PBPK-QSP Platform for Renal–Cardiovascular Pharmacology: Simulating RAAS-Targeted Therapies and Drug-Induced Kidney Injury
Thursday 7 May, 2026
Objectives Mechanistic modeling offers a unique opportunity to integrate complex renal and cardiovascular physiology with pharmacological interventions. Dogs have historically…
Read moreDrug interaction between pyrazinamide and standard- and high-dose rifampicin
Thursday 7 May, 2026
Background and objective: Pyrazinamide is an essential component of the first-line combination treatment for drug-susceptible tuberculosis (TB), taken by approximately…
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