Thursday 16 October, 2025
Objectives: The aim of this work is to validate model predictions from PhysPK biosimulation software using a previously published semi-mechanistic…
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Population modeling of tumor growth curves, the reduced Gompertz model and prediction of the age of a tumor
Thursday 16 October, 2025
Introduction: Tumor growth curves are classically modeled by ordinary differential equations. In analyzing the Gompertz model several studies have reported…
Read moreMechanistic models of cancer-immune cycle and immunotherapies
Thursday 16 October, 2025
Introduction: Immuno-oncology (IO), where treatments mobilize a patient’s immune system to fight cancer and provide lasting therapeutic benefit, is the…
Read morePharmacokinetics after intravitreal injection of a new anti-angiogenic therapeutic compound in rabbit eyes
Thursday 16 October, 2025
Introduction and objectives: Proliferative diabetic retinopathy (PDR) is the more advanced form of diabetic retinopathy disease, with formation of new…
Read moreTowards a qualitative systems biology model to study the effect of blood flow responsive CCM and NO signaling on endothelial cell morphology
Thursday 16 October, 2025
Objectives: Endothelial cells (ECs) line the interior surface of blood vessels. They are exposed to fluid shear stress (FSS), a…
Read moreTowards understanding vascular (dys)regulation by linking endothelial cell morphology and blood vessel geometry
Thursday 16 October, 2025
Objectives: The geometry of the vasculature is largely influenced by its biophysical environment, which impacts the morphology of endothelial cells…
Read moreA semi-mechanistic dose-finding design in oncology using pharmacokinetic/pharmacodynamic modeling
Thursday 16 October, 2025
Objectives: While a number of phase I dose-finding designs in oncology exist, the commonly used ones are either algorithmic or…
Read moreBioavailability and the Variability of Posaconazole Exposure in Healthy Volunteers Using a Population Pharmacokinetic Analysis
Thursday 16 October, 2025
Objectives: Posaconazole is a broad-spectrum, systemic triazole antifungal drug and is widely used for prophylaxis and treatment of invasive fungal…
Read morePharmacokinetics of fluconazole in obese and non-obese adults upon a semi-simultaneous oral and IV study design
Thursday 16 October, 2025
Objectives: Fluconazole is frequently used for the treatment of (invasive) Candida infections. Obesity, and especially morbid obesity, is known to…
Read moreAn integrated population pharmacokinetic analysis for posaconazole oral suspension, delayed-release tablet, and intravenous infusion in healthy volunteers
Thursday 16 October, 2025
Objectives: Posaconazole is widely used for prophylaxis and treatment of invasive fungal diseases. Due to limited and variable absorption for the…
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