Thursday 16 October, 2025
Introduction: HIV therapeutic vaccines are currently developed with the objective of long-term viral control in the absence of anti-retroviral treatment…
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Dynamics of the humoral immune response to a two-dose heterologous vaccine regimen against Ebola virus.
Thursday 16 October, 2025
Introduction: The two-dose heterologous vaccine regimen Ad26.ZEBOV,MVA-BN-Filo against Ebola virus has been evaluated in multiple clinical trials. However, the long-term…
Read moreSARS-CoV-2 mechanistic correlates of protection in non-human primates: insight from modelling response to vaccines.
Thursday 16 October, 2025
Objectives: Despite the development of efficient SARS-CoV-2 vaccines, the identification of correlates of protection (CoP) is essential for further vaccine development….
Read moreQuantitative systems pharmacology model of key intraneuronal pathways regulating toxic protein accumulation in Alzheimer’s disease
Thursday 16 October, 2025
Objectives: Alzheimer’s disease (AD) is a complex neurodegenerative disorder, its pathogenesis mechanism is still debated and there is no effective…
Read moreEstimation of equipotent doses of the oral selective glucocorticoid receptor modulator (oSGRM) AZD9567 and prednisolone based on ex vivo TNFa inhibition after LPS stimulation
Thursday 16 October, 2025
Introduction: AZD9567 is an oral selective glucocorticoid receptor modulator (oSGRM) aimed for the treatment of inflammatory disease [1]. It has…
Read morePharmacometrics: A shot in the arm for vaccine discovery and development ~or~ Vaccines are not immune to the charms of pharmacometrics
Thursday 16 October, 2025
Objectives: The objective is to (1) inform the audience about pharmacometrics (PMX) opportunities in vaccine discovery and development (D&D), and…
Read moreAssessment of bioequivalence outcomes of oral formulations containing racemic ibuprofen through a chiral physiologically-based pharmacokinetic model
Thursday 16 October, 2025
Introduction: The characterization of the time course of ibuprofen (IBU) enantiomers can be useful in the selection of the most sensitive…
Read moreChirality matters: physiologically based pharmacokinetic modelling of ibuprofen enantiomers
Thursday 16 October, 2025
Introduction/Objective: Ibuprofen is a non-steroidal anti-inflammatory drug administered in its racemic form containing equal amounts of R-ibuprofen (pharmacologically inactive) and S-ibuprofen…
Read moreA Physiologically Based Pharmacokinetic Model for Open Acid and Lactone Forms of Atorvastatin and Its Two Metabolites
Thursday 16 October, 2025
Introduction: Atorvastatin (ATS), one of the most prescribed statin worldwide, shows low oral bioavailability and non-linear pharmacokinetics (PK) due to its…
Read morePhysiologically Based Pharmacokinetic Model for Atorvastatin: New Insights in Enzymatic and Transport Processes.
Thursday 16 October, 2025
Introduction: Atorvastatin (ATS) is one of the most frequently prescribed 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase reversible inhibitors, also known as…
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