Thursday 16 October, 2025
Number of characters: 4429/4500 Objectives: The standard error (SE) of the maximum likelihood estimate (MLE) of the population parameter vector…
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Model-based analysis of PK equivalence: assessing the impact of model misspecification
Thursday 16 October, 2025
Introduction: Model-based approaches (MB-TOST) have been advocated to test for equivalence in sparse PK studies but questions about their performance…
Read moreThe importance of model selection for a priori model informed precision dosing of vancomycin
Thursday 16 October, 2025
Objectives: Vancomycin is a commonly used antibiotic for gram positive infections at the Intensive Care unit. However, in 2020 only…
Read moreA step towards automated and individualized first dose of vancomycin
Thursday 16 October, 2025
Objectives: Vancomycin is a commonly used antibiotic at Intensive Care Units for gram-positive infections.1 With the current dosing regimen, the…
Read moreExplainable machine learning for time-to-event analysis: exploring time-dependent covariate effects on models of small cell lung cancer
Thursday 16 October, 2025
Objectives: Traditional time-to-event analysis relies on parametric or semi-parametric models, such as the Cox proportional hazards model, to estimate the effects…
Read moreRole of tree-based machine learning algorithms in prognostic pattern detection: an Extensive-Disease Small Cell Lung Cancer (ED-SCLC) study
Thursday 16 October, 2025
Introduction: Retrospective studies using clinical data from cancer patients usually are analysed using Cox Proportional Hazards CPH. [1] This approach has…
Read moreOvercoming the discrepancies between clinical trials and real-world data of small cell lung cancer chemotherapy. A data-driven approach to learn across real-world evidence studies
Thursday 16 October, 2025
Objectives: Since the 21st Century Cures Act in 2015, the potential for translating between real-world data (RWD) and clinical trials…
Read moreA model based approach to infer overall survival (OS) in hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (HR+/HER2- mBC)
Thursday 16 October, 2025
Introduction: Assessment of benefit in clinical trials of systemic therapy for HR+/HER2- mBC is commonly performed by using progression free…
Read morePopulation pharmacokinetic modelling of levetiracetm in criticaclly ill patients. Influence of creatinine clearance on the probability to attain target concentrations.
Thursday 16 October, 2025
Objectives: Levetiracetam is a broad-spectrum antiepileptic drug commonly used in seizure treatment and prophylaxis in the intensive care units (ICUs). Augmented…
Read morePopulation pharmacokinetic modelling and Monte Carlo simulation of piperacillin administered as extended infusion in critically ill patients
Thursday 16 October, 2025
Introduction/Objectives: Piperacillin/tazobactam is a beta-lactam/beta-lactamase inhibitor combination with activity against gram-positive and gram-negative aerobic and anaerobic bacteria [1]. Piperacillin exhibits…
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