Thursday 16 October, 2025
Background: Clindamycin is an antibiotic frequently used in the treatment of bone and joint infections (BJIs) and is often co-administered…
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Implementation of Estimation Step Refinements to Support Runtime Reduction for Model Building in NONMEM® 7
Thursday 16 October, 2025
Introduction: Overall, as pharmacometrics advances as a powerful computational tool, model complexity describing biological systems has also increased. Computer runtime…
Read moreSimulation of the impact of unbound fraction variations on the predictive performance of a piperacillin-tazobactam population pharmacokinetic model.
Thursday 16 October, 2025
Introduction: Piperacillin-tazobactam is an extended-spectrum β-lactam/β-lactamase inhibitor antibiotic frequently prescribed in intensive care units. In clinical practice, the unbound concentration is…
Read moreModel-informed precision dosing: can the administration method influence the predictive performance of a model? An example with piperacillin.
Thursday 16 October, 2025
Introduction: Piperacillin is an extended-spectrum β-lactam antibiotic frequently prescribed in intensive care units (ICUs). Critically ill patients constitute a complex…
Read moreLefamulin exposure in soft tissues: population pharmacokinetics and pharmacokinetic/pharmacodynamic target attainment
Thursday 16 October, 2025
Objectives: Lefamulin is the first pleuromutilin antibiotic for systemic application in humans, and currently only approved for bacterial community-acquired pneumonia…
Read moreModel-based comparison of antibiotic activity at target-site concentrations: a case study with ceftaroline and lefamulin for soft-tissue infections
Thursday 16 October, 2025
Objectives: Comparing antibiotic activity of different drugs using traditional pharmacokinetic-pharmacodynamic (PK-PD) targets has limitations: the targets may have been derived…
Read moreTargeted temperature management reduces CYP2C19 metabolism: a population pharmacokinetic study using pantoprazole
Thursday 16 October, 2025
Introduction: Targeted temperature management (TTM) is part of standard post-resuscitation care. TTM-induced hypothermia and the systemic inflammation that often follows…
Read moreApplication of a PBPK Model to Predict the Required Ceftazidime Concentration and Duration in Maternal and Umbilical Plasma Prior to Caesarean Section in Virtual Pregnant Women with Different Renal Function
Thursday 16 October, 2025
Objectives: Ceftazidime injection has been used as prophylaxis for emergency caesarean section. The drug is given just before the surgery that…
Read moreSame Dissolution Profile – Different Virtual Bioequivalence (VBE) Outcome! Input-Dependent Propagation of Between Subject Variability (BSV) in Gut Physiology to Dissolution and VBE
Thursday 16 October, 2025
Objectives: Physiologically based pharmacokinetic (PBPK) models can be used to conduct virtual bioequivalence (VBE) studies. There are different ways to input…
Read moreComputation of standard errors at finite distance in non linear mixed effects models
Thursday 16 October, 2025
Introduction: Longitudinal data are often collected in clinical trials, and non linear mixed effects models (NLMEM) are powerful to model…
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