Thursday 16 October, 2025
Introduction: Morphine remains the primary treatment option for chronic pain. Morphine acts by binding to the µ-opioid receptor (µ-OR) in…
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Prediction of CNS Target Engagement of Pain reliving Drugs in Health and Chronic Pain conditions
Thursday 16 October, 2025
Introduction: Chronic pain is a prevalent medical problem affecting 20% of Europeans [1] with an annual economic burden of approx….
Read moreMu-opioid receptor binding of morphine and its main metabolites: impact of non-linear BBB transport of morphine.
Thursday 16 October, 2025
Introduction: Chronic pain is a difficult disease, due to the complexity of neuronal plasticity [1,2], and many other factors involved….
Read moreInterspecies scaling of host inflammatory response during infection
Thursday 16 October, 2025
Introduction: Sepsis is defined as a life-threatening condition that is caused by an disregulated host response to an infection, and…
Read morePharmacokinetic modeling based on physiology (PBPK): an innovative strategy for optimization of Piperacillin pharmacotherapy
Thursday 16 October, 2025
Introduction/Objectives: PBPK are bottom-up models that integrate physiological information of the organism with the physicochemical characteristics of the drug, allowing a…
Read moreModel-informed precision dosing web tool of busulfan for Brazilian pediatric patients
Thursday 16 October, 2025
Introduction: Therapeutic drug monitoring is widely practiced for busulfan (Bu), with the aim of ensuring exposure into the therapeutic zone [1]….
Read moreThe Markov chain survival modeling platform for cancer burden assessment
Thursday 16 October, 2025
Introduction: The socio-economic impact of cancer remains considerable and is poorly understood. It is associated with higher morbidity and mortality and…
Read moreA dermal physiologically-based pharmacokinetic (PBPK) model of clobetasol propionate to predict systemic exposure in eczema and dermatitis patients
Thursday 16 October, 2025
Introduction: Clobetasol propionate (CP) is a potent topical corticosteroid indicated for the short-term treatment of psoriasis, atopic dermatitis (AD, eczema) and…
Read moreSubspace MCMC algorithm for Bayesian parameter estimation of hierarchical PK/PD models in Pumas
Thursday 16 October, 2025
Objectives: To speed up the sampling from high-dimensional posteriors of hierarchical Pumas [1] models with a high correlation between the…
Read morePopulation pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of an intravenous nanocrystal formulation
Thursday 16 October, 2025
Introduction: Itraconazole is a broad-spectrum antifungal agent used to treat various fungal infections, including aspergillosis, and for prophylaxis of invasive fungal…
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