Thursday 16 October, 2025
Objectives Clearance (CL) and oral bioavailability (F) are important drivers of oral drug exposure and dose selection. Midazolam is extensively…
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Development of a time dependent clearance model for busulfan in paediatric patients to investigate dosing adjustment scenarios
Thursday 16 October, 2025
Introduction: Busulfan is a chemotherapy drug used in haematopoietic stem cell transplantation. While several studies have observed a reduction in…
Read moreUnexpectedly low drug exposures among Ugandan patients with TB and HIV receiving high-dose rifampicin.
Thursday 16 October, 2025
Objectives: Rifampicin (RIF) is the key component of first-line regimens for drug‑susceptible tuberculosis (TB), with a concentration-dependent bactericidal effect (1)….
Read morePopulation pharmacokinetic analysis of the drug interaction between ritonavir-boosted atazanavir and rifampicin
Thursday 16 October, 2025
Introduction: Boosted protease inhibitors like atazanavir/ritonavir (ATV/r) are commonly prescribed as second-line antiretroviral therapy (ART) for HIV in low-income countries. However,…
Read moreA probabilistic approach to calculating probability of achieving target pharmacological effect levels for a novel orally administered antibacterial chemotherapeutic
Thursday 16 October, 2025
Objectives: To apply a new probabilistic PK-PD (Pharmacokinetics-Pharmacodynamics) framework to predict the probability of achieving target pharmacological effect levels of a…
Read moreA meta-analysis for predicting early bactericidal activity of beta-lactam antibiotics against pulmonary tuberculosis
Thursday 16 October, 2025
Introduction: Tuberculosis is a leading cause of mortality among infections, with 6.4 million new diagnosis and 1.6 million deaths in…
Read morePopulation PK-PD modeling and simulation of zolpidem to evaluate dosage regimen for sex effect in healthy Korean volunteers
Thursday 16 October, 2025
Objectives: In 2013, the recommended initial dose of zolpidem changed to 5 mg for female in FDA[1]. The concern is…
Read moreOpioids distribution in human CNS might be altered due to pain-related increase of BBB permeability.
Thursday 16 October, 2025
Objectives: Chronic pain is an undesirable condition with drug treatments being mainly ineffective and are often associated with adverse effects….
Read moreP-glycoprotein mediated drug-drug interaction at the blood-brain barrier on morphine brain distribution
Thursday 16 October, 2025
Introduction/objectives: Transporter-mediated drug-drug interactions (DDIs) are studied in intestine, liver, and kidney. However, considerations of the effect of DDIs on…
Read morePrediction of unbound partition coefficients at the blood-brain barrier (Kp,uu,BBB) using machine learning and its integration into a physiologically-based pharmacokinetic modeling workflow
Thursday 16 October, 2025
Introduction/Objective: The rate and extent of blood-brain barrier (BBB) transport are critical parameters for central nervous system (CNS) drug distribution….
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