Thursday 16 October, 2025
Objectives: Anticancer regimens are often a delicate compromise between dose intensity and acceptable toxicity, for example neutropenia. The aim of…
Read morePoster: Study Design
Trial Sample Size Estimation and Study Design Assessment using Monte Carlo Sampling
Thursday 16 October, 2025
Objectives: Construct a simulated clinical trial as close to clinical reality as possible benefitting from available clinical information. Methods: To…
Read moreMultivariate patient simulation for clinical trial optimization in COPD
Thursday 16 October, 2025
Objectives: Clinical Trial Simulation (CTS) can be a valuable tool to improve drug development [1]. However, in order to obtain…
Read moreDevelopment of Sparse Sampling Study of Oral Ciprofloxacin for Severely Malnourished Children
Thursday 16 October, 2025
Objectives: The population approach is a powerful tool to estimate pharmacokinetic (PK) parameters and to identify inter- and intra-individual variability…
Read moreOptimisation of Screening Experiments for the Assessment of Analgesic Effects
Thursday 16 October, 2025
Objectives:Experimental protocols in preclinical drug screening are often based on empirical criteria such as best guess approaches. Practical constraints prevent…
Read moreDose and dose schedule optimization of anticancer drugs
Thursday 16 October, 2025
Objectives: Anticancer drug dose and dose schedule are known to affect the tumor response. Tumor growth inhibition (TGI) models establish…
Read moreDesigning a dose-response study analysed by nonlinear mixed effects models
Thursday 16 October, 2025
Objectives: Nonlinear mixed effects models (NLMEM) can be used to analyse dose-response trials with several doses in each patient. The…
Read moreEvaluation of Fisher information matrix using Gaussian quadrature in nonlinear mixed effects models: application to dose-response trials
Thursday 16 October, 2025
Objectives: Nonlinear mixed effects models (NLMEM) can be used to analyse dose-response trials where each patient received several doses. Design…
Read moreOptimal design for a population pharmacokinetic study of oxycodone in preterm neonates, neonates and infants
Thursday 16 October, 2025
Objectives: While the pharmacokinetics of oxycodone in children older than 6 months of age has been characterized, only one study…
Read moreOptimal design of a dichotomous Markov-chain mixed-effect sleep model
Thursday 16 October, 2025
Objectives: Optimal design (OD) for discrete-type responses have been derived using generalized linear mixed models [1] and simulation based methods…
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