Thursday 16 October, 2025
Objectives: IOV may adversely affect the precision of maximum a posteriori (MAP) estimated individual parameters and have long been recognized…
Read morePoster: Study Design
Robust optimal design of ciprofloxacin time-kill curve experiments with respect to autocorrelation
Thursday 16 October, 2025
Objectives: Residual autocorrelation (AC) is shown to be of importance in optimal experimental design with different magnitudes of correlation resulting…
Read moreOptimal two-stage design for a population pharmacokinetic study in children
Thursday 16 October, 2025
Objectives: Pharmacokinetic (PK) studies in children are mainly analysed by nonlinear mixed effect-models [1,2] as recommended in guideline [3]. Approaches…
Read moreDesign evaluation in nonlinear mixed effect models: influence of covariance between random effects
Thursday 16 October, 2025
Objectives: Nonlinear mixed effect models (NLMEM) are increasingly used during drug development and for analysis of longitudinal data obtained in…
Read moreInfluence of the ratio of the sample sizes between the two stages of an adaptive design: application for a population pharmacokinetic study in children
Thursday 16 October, 2025
Objectives: Nonlinear mixed-effect models are used to analyse pharmacokinetic (PK) data during drug development, notably in pediatric studies[1,2]. To optimise…
Read morePopED lite an easy to use experimental design software for preclinical studies
Thursday 16 October, 2025
Objectives: In drug discovery, accurate and precise estimation of drug potency from in vivo data is crucial to select the…
Read moreDose Regimen Assessement For Oral Fexinidazole
Thursday 16 October, 2025
Objectives: Fexinidazole, a 5-nitroimidazole, is being developed as a new oral treatment for Human African Trypanosomiasis. The aim of the…
Read moreSimultaneous Optimization of Sampling Strategies for Parent and Metabolite Data Taking into Account a Body Weight Distribution: Applications to Paediatric Studies
Thursday 16 October, 2025
Objectives: A study design of a drug with an active metabolite must assess the pharmacokinetics (PK) of the parent drug…
Read moreOptimal sampling and model-based dosing algorithm for busulfan in bone marrow transplantation patients.
Thursday 16 October, 2025
Objectives: Busulfan is an alkylating agent used as part of a conditioning regimen in patients undergoing bone marrow transplantation. Busulfan…
Read moreAn Application of Optimal Design to Dose Selection and Sample Size Determination with a Negative-Binomial Exposure-Response Model for a Phase IIb Study
Thursday 16 October, 2025
Objectives: Previously, late stage clinical trials had been performed with drug Tx, enabling the development of an exposure-response model for…
Read more