Thursday 16 October, 2025
Objectives: The aim of this study was to establish the population pharmacokinetics (PK) of amikacin in newborns from serum concentration…
Read morePoster: Paediatrics
Predicting antiepileptic drug concentrations for combination therapy in children with epilepsy.
Thursday 16 October, 2025
Objectives: Despite the wide number of publications on the pharmacokinetics of antiepileptic drug combinations, drug-drug interactions have not been accurately…
Read moreOptimal design for a dexmedetomidine pharmacokinetic trial in mechanically ventilated neonates with single organ respiratory failure.
Thursday 16 October, 2025
Objectives: The European legislation has created an increased demand for clinical trials in neonates and infants. However, paediatric protocols still…
Read moreCharacterisation of response and disease progression in paediatric epilepsy
Thursday 16 October, 2025
Objectives: Differences in response rate and efficacy occur across patients and across epilepsy types. Such differences may be explained by…
Read moreDried Blood Spots and Sparse Sampling: A perfect combination for minimally invasive PK/PD studies in children
Thursday 16 October, 2025
Background: Dried blood spots (DBS) have recently received considerable interest for application to PK studies. The technique requires a micro…
Read moreFentanyl pharmacokinetic and pharmacodynamic (PK/PD) estimation in neonates and infants using allometric and ontogeny methods
Thursday 16 October, 2025
Background: Use of fentanyl for prolonged sedation in neonates and infants has become increasingly widespread. Usually, dose schedules are extrapolated…
Read moreDeferiprone sampling optimisation in a pharmacokinetic bridging study including children with β-thalassaemia
Thursday 16 October, 2025
Objectives: Practical and ethical constraints impose special requirements for clinical trials in children. The application of population PK analysis to…
Read morePopulation Pharmacokinetics of Theophylline in Premature Korean Infants
Thursday 16 October, 2025
Objectives: The aim of this study was to investigate the population pharmacokinetics of theophylline in premature Korean infants and to…
Read moreThe influence of variability in serum prednisolone pharmacokinetics on clinical outcome in children with nephrotic syndrome, based on salivary sampling combined with translational modeling and simulation approaches from healthy adult volunteers
Thursday 16 October, 2025
Background: Prednisolone (PLN) represents the cornerstone for the treatment of childhood nephrotic syndrome (NS) since 1950’s. However, pediatric patients show…
Read moreDesign optimisation of a pharmacokinetic study in the paediatric development of a drug
Thursday 16 October, 2025
Objectives: In the context of the Paediatric Investigation Plan [1] in place since 2007, pharmacokinetic (PK) studies in children are…
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