Thursday 16 October, 2025
Objectives: Different tacrolimus pharmacokinetics (PK) models have been proposed to characterize the tacrolimus PK variability observed in pediatric liver transplantation….
Read morePoster: Paediatrics
Population Pharmacokinetics of Twice Daily Zidovudine (ZDV) in HIV-Infected Children and an Assessment of ZDV Exposure Following WHO Dosing Guidelines
Thursday 16 October, 2025
Objectives: Zidovudine (ZDV) is a component of HIV therapy for children but limited PK data are available on the widely…
Read moreAge-Corrected Creatinine is a Significant Covariate for Gentamicin Clearance in Neonates
Thursday 16 October, 2025
Objectives: Gentamicin is an antibiotic with a narrow therapeutic window, making therapeutic drug monitoring (TDM) vital. However, currently there is no…
Read morePaediatric Pharmacokinetic methodologies: Evaluation and comparison
Thursday 16 October, 2025
Objectives: The “first dose in children” could be determined mainly by two approaches: A physiological approach (PBPK “Physiollogically based PharmacoKineticsmodel)…
Read moreExposure to the biological anti-thymocyte globulin (ATG) in children receiving allogeneic-hematopoietic cell transplantation (HCT): towards individualized dosing to improve survival
Thursday 16 October, 2025
Objectives: To prevent graft versus host disease (GvHD) and rejection in hematopoietic cell transplantation (HCT), children receive anti-thymocyte globulin (ATG),…
Read moreMapping in vitro and in vivo derived CYP3A ontogeny function: A critical comparison between various ontogeny models
Thursday 16 October, 2025
Objectives: The aims of this study are to:1) Deconvolute components of clearance based on known ontogenies and explore any age-dependence of…
Read morePharmacokinetic/Pharmacodynamic Simulations Of The vWF Targeting Nanobody® ALX-0081 In Pediatric Patients With TTP
Thursday 16 October, 2025
Objectives: Nanobodies® are therapeutic proteins based on the smallest functional fragments of heavy chain antibodies, naturally occurring in Camelidae. ALX-0081 is a bivalent Nanobody® drug…
Read morePopulation pharmacokinetic study of gentamicin: a retrospective analysis in a large cohort of neonate patients
Thursday 16 October, 2025
Objectives: Gentamicin is one of the most commonly prescribed antibiotics for suspected or proven infection in newborns. Because of age-associated…
Read morePopulation Pharmacokinetics of Intravenous Busulfan in Children: Revised Body Weight-Dependent NONMEM® Model to Optimize Dosing
Thursday 16 October, 2025
Objectives: Busulfan (Bu), a DNA-alkylating agent, is widely used for conditioning prior to bone marrow transplantation in both children and…
Read morePopulation pharmacokinetics of Zidovudine and its metabolite in HIV-1 infected children: Evaluation doses recommended
Thursday 16 October, 2025
Objectives: To describe Zidovudine (ZDV) pharmacokinetics (PK) and its biotransformation to its metabolite (G-ZDV) in HIV-infected children, to identify factors…
Read more