Thursday 16 October, 2025
Objectives: For many diseases, such as psychiatric ones, mechanistic knowledge of the progression of the disease and the interaction between…
Read morePoster: New Modelling Approaches
Non-Parametric Bayesian Fitting: A Novel Approach to Population Pharmacokinetic Modeling
Thursday 16 October, 2025
Objectives: Compared with most parametric population modeling methods, our non-parametric (NP) expectation maximization (EM) algorithm calculates exact, rather than approximate…
Read moreA Systems Pharmacology model of the nerve growth factor (NGF) pathway to aid drug discovery and development
Thursday 16 October, 2025
Objectives: The aim of this work was to integrate the knowledge of the biology of NGF response in a Quantitative…
Read morecPirana: command-line user interface for NONMEM and PsN
Thursday 16 October, 2025
Objectives: Develop a “lite” version of Pirana for use on the UNIX command-line. Background: Graphical user interfaces (GUIs) for NONMEM…
Read moreIdentification of optimal NONMEM models using a multi-objective genetic algorithm.
Thursday 16 October, 2025
Objectives: Investigate multi-objective genetic algorithm (MOGA) to identify optimal NONMEM models. Methods: MOGA is a global search algorithm that is…
Read moreMonoclonal Antibody-Drug Conjugates (ADC): Simplification of Equations and Model-Independent Assessment of Deconjugation Rate
Thursday 16 October, 2025
Objectives: To simplify equations that describe distribution, deconjugation, elimination and interaction with the target of antibody-drug conjugates (ADC) under specific…
Read moreA semi-mechanistic gastric emptying model for double peaks in pharmacokinetics using LDOPA data
Thursday 16 October, 2025
Objectives: Following PO administration, double-peaked drug concentration-time profiles in plasma can be explained by a number of different mechanisms: delayed…
Read moreImmunogenicity in PK of Monoclonal Antibodies: Detection and Unbiased Estimation of Model Parameters
Thursday 16 October, 2025
Objectives: To propose and evaluate methods for immunogenicity detection and unbiased estimation of model parameters in the presence of immunogenicity….
Read moreOrganization of Target-Mediated Disposition (TMD) Models including Michaelis-Menten (MM), rapid-binding (RB), and quasi-steady-state (Qss) models
Thursday 16 October, 2025
Objectives: To illustrate a rigorous way with which simplifications of the general TMD model are derived; to organize TMD models…
Read moreConstructing the disease trajectory of CDR-SOB in Alzheimer’s disease progression modelling
Thursday 16 October, 2025
Objectives: To establish the disease onset time (DOT) and disease trajectory (DT) concepts[1] by developing an original natural history population…
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