Thursday 16 October, 2025
Objectives: Classical compartment models are successfully used to characterize the pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs). These models, however,…
Read morePoster: New Modelling Approaches
Modeling of pain scores from a flexible titration study using an ordered categorical approaches
Thursday 16 October, 2025
Objectives: In clinical pain studies, the primary endpoint is frequently reported using an 11-point Numeric Rating Scale, ranging from 0,…
Read moreEvaluation of the long-term decline of platelets following Navitoclax (ABT-263) administration in Cancer Patients with a semi-physiological pharmacodynamic model
Thursday 16 October, 2025
Objectives: Navitoclax (ABT-263) is a novel small molecule that inhibits Bcl-2 family proteins and promotes apoptosis. Thrombocytopenia is a primary…
Read moreItem response theory for the analysis of the placebo effect in Phase 3 studies of schizophrenia
Thursday 16 October, 2025
Objectives: Disease severity in schizophrenia is quantified using the PANSS scale, a composite psychological and functional scale divided into 7…
Read moreA semi-physiologic mathematical model describing pharmacokinetic profile of an IgG monoclonal antibody mAbX after IV and SC administration in human FcRn transgenic mice.
Thursday 16 October, 2025
Objectives: To characterize the observed PK profiles of mAbX after IV and SC administration in variants of human FcRn transgenic…
Read moreMulti-objective Optimal Control of Non-Viral Gene Delivery
Thursday 16 October, 2025
Objectives: Obtain optimal cellular exposure and transfection by formulating and solving a constrained multi-objective optimal control problem to compute the…
Read moreResponse type modelling and clinical trial simulation.
Thursday 16 October, 2025
Objectives: Drug development in depression is a particular challenge since high apparent variability in response is obscuring a clear dose-response…
Read moreSolution and implementation of distributed lifespan models
Thursday 16 October, 2025
Objectives: A realistic assumption for a (cell) population is that every individual has its own and unique lifespan. Krzyzanski, Woo…
Read moreA new, second-order indirect model of depression time course
Thursday 16 October, 2025
Objectives: The limited understanding of placebo effect and drug action in psychiatric diseases has led to a widespread use of…
Read moreSecond-order indirect response modelling of complex biomarker dynamics
Thursday 16 October, 2025
Objectives: Biomarker dynamics in response to drug action may not always be fully understood. Redundant pathways, tolerance, feedback and counter-regulation…
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