Thursday 16 October, 2025
Introduction While in many pharmacokinetic (PK) and pharmacodynamic (PK-PD) modeling approaches only a a straightforward but continuous description of PK…
Read morePoster: Methodology - New Modelling Approaches
A new model-based approach to compare toxicity of a series of compounds based on their categorical toxicity scores
Thursday 16 October, 2025
Objectives: The toxicity of a series of new antibody-drug conjugates (ADCs) have been assessed pre-clinically. The outcome of these toxicity…
Read moreCharacterising the onset of response using public domain data and MBMA: application cases in Atopic Dermatitis and Psoriatic Arthritis
Thursday 16 October, 2025
Objectives: Immune-mediated inflammatory diseases (IMIDs) comprise a group of conditions sharing common immune pathways and are often treated with same…
Read morePerformance of Machine Learning Algorithms for Model Selection
Thursday 16 October, 2025
Introduction/Objectives: pyDarwin (1) is an open source python package for population PK model selection. The objective is to evaluate performance…
Read moreApproximations of Target-Mediated Drug Disposition (TMDD) Equations for Systems with 1:2 and 2:1 Drug-Target Binding Stoichiometry
Thursday 16 October, 2025
Background: TMDD equations were initially written and are used assuming 1:1 stoichiometry of drug-target binding even though many biological systems do…
Read morevc-MMAE antibody-drug conjugates: a unified model describes pharmacokinetics of eight different compounds
Thursday 16 October, 2025
Objectives: ADCs developed using Vc-MMAE platform share the same antibody technology, linker, and toxin (MMAE). The similarity of ADC structures…
Read morePerformance evaluation of the Automatic Model Development (AMD) tool with real population pharmacokinetic datasets from clinical drug development projects
Thursday 16 October, 2025
Introduction: The Automatic Model Development (AMD) tool in Pharmpy is an open source tool for automatic building of population pharmacokinetic…
Read moreAutomatic framework for bioequivalence studies from In Vitro test to In Vivo study design
Thursday 16 October, 2025
Objectives: The traditional deconvolution-based method of in vitro-in vivo correlation (IVIVC) for bioequivalence (BE) studies pre-dates modern population approaches to PK…
Read moreInfluence of clinical trial design to detect drug effect in systems with within subject variability
Thursday 16 October, 2025
Objectives: In many clinical development programs, identification of drug effect is attempted through hypothesis test based on data from a…
Read morePK of acetaminophen and its metabolites in preterm and term neonates using relevant external background information in a Bayesian approach with Stan
Thursday 16 October, 2025
Objectives: Drugs used in the adult population are urgently required in the treatment of pre- and term neonates. Acetaminophen (APAP)…
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