Thursday 16 October, 2025
Objectives: Methylphenidate hydrochloride (MPH) is a central nervous system stimulant and is used as a first line of treatment for…
Read morePoster: Methodology - New Modelling Approaches
A Mini-Tutorial on Campsis: The R-Based PK/PD Simulation Suite
Thursday 16 October, 2025
Introduction: Campsis (www.campsis.org) is a suite of R packages designed to facilitate the setup and execution of PK/PD simulations in…
Read moreComparison of the mechanistic static in vivo approach to a PBPK approach for prediction of metabolic drug-drug interactions.
Thursday 16 October, 2025
Objectives: Quantitative prediction of the magnitude of a drug-drug interaction (DDI) is useful to identify the clinical interaction studies to…
Read morePharmacodynamic age structured population model for cell trafficking
Thursday 16 October, 2025
Introduction: Cell trafficking encompasses movement of the immune system cells (e.g., granulocytes, lymphocytes) between the blood and the extravascular tissues…
Read moreItem Response Theory Model as Support for Decision-Making: Simulation Example for Inclusion Criteria in Alzheimer’s Trial
Thursday 16 October, 2025
Objectives: Item Response Theory (IRT) has been introduced in pharmacometrics for the characterization of the Alzheimer’s Disease (AD) Assessment Scale –…
Read moreHandling Underlying Discrete Variables with Mixed Hidden Markov Models in NONMEM
Thursday 16 October, 2025
Objectives: Concomitant infection impact on CD4 counts or rescue medication effect on pain score are examples of covariate relationships often not…
Read moreUse of distributed delay in PML
Thursday 16 October, 2025
Objectives: ODEs incorporating delay are called Delay Differential Equations (DDEs). They can be thought of as convolving an input function with…
Read moreMixed-effect models for longitudinal exposure to co-administered drugs and time-to-event data: prediction of risk of graft failure in renal transplant patients.
Thursday 16 October, 2025
Objectives: This study aimed to investigate, in adult kidney transplant recipients, the relationship between longitudinal exposure to co-administered immunosuppressive drugs…
Read moreUnderstanding the gastrointestinal absorption of drugs using Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models: Focus on Biowaivers
Thursday 16 October, 2025
Introduction: The introduction of the Finite Absorption Time (F.A.T.) [1,2] concept led to the development of PBFTPK models [3], successfully…
Read moreA Mechanistic Modeling Approach Characterizing the Interaction of Pharmacokinetics and Pharmacodynamics of a Monoclonal Antibody and the Supply/Synthesis of its target in Cynomolgus Monkey
Thursday 16 October, 2025
Objectives: To develop a mechanistic PK/PD model simultaneously describing the nonlinear interaction between antibody and its target, including drug disposition,…
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