Thursday 16 October, 2025
Introduction: Automatic differentiation (AD) is a widely used method for calculating gradients in neural networks (NN) [1]. The traditional method…
Read morePoster: Methodology - Estimation Methods
Understanding the numerical issues in and instability of fits based on the laplace approximation
Thursday 16 October, 2025
Introduction The application of the Laplace Approximation to the Marginal Log-Likelihood function has enabled researchers to analyse many statistically realistic…
Read moreA Bayesian Workflow for Minimal PBPK Modeling: A Case Study with Dapagliflozin
Thursday 16 October, 2025
Objectives: Dapagliflozin is a sodium-glucose cotrasporter-2 inhibitor originally developed for the treatment of type 2 diabetes mellitus and subsequently approved…
Read moreEfficient and Informed Model Development for NLME Models with Poor Parameter Identifiability
Thursday 16 October, 2025
Background Poor-identifiability of parameters pose a major challenge in population modeling, slowing down model development and potentially leading to unreliable…
Read moreCohort population estimates of covariance matrix for sparse pharmacokinetic data
Thursday 16 October, 2025
Introduction: Cohort population approximates multivariate normal distribution with a discrete number of point distributions (cohorts) so that their first and…
Read moreModeling Huntington’s disease progression using a bounded integer approach
Thursday 16 October, 2025
Introduction/Objectives: Huntington’s disease (HD) is a rare, fatal, and progressive neurodegenerative disorder that has been challenging to develop disease modifying…
Read moreCausal mediation analysis in a pharmacometrics context
Thursday 16 October, 2025
Objectives Mediation analyses can provide strong support for biomarker development by demonstrating that a biomarker mediates a (large) part of…
Read moreOpenPMX software for FOCE-I estimation
Thursday 16 October, 2025
Introduction: The estimation of mixed effect models from data is a backbone of pharmacometrics in industry and academia. Calculating a…
Read moreEfficiency comparison of different exact gradient solutions in First Order conditional methods mixed effect Non Linear Regression
Thursday 16 October, 2025
Objectives: Compare two alternative approaches to parameter estimation in the first order conditional with interaction (FOCE-I) method mixed effect non-linear…
Read moreLeveraging Two-Stage d Global Sensitivity Analysis method to inform parameter estimation in PBPK models
Thursday 16 October, 2025
Introduction: Therapeutic drug monitoring represents one of the main applications of pharmacometrics in the clinical setting. Parameter estimations are routinely…
Read more