Thursday 7 May, 2026
Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool for integrating in vitro and in vivo data to predict drug…
Read morePoster: Methodology - Estimation Methods
OpenPMX software for simulation and estimation in pharmacometrics
Thursday 7 May, 2026
Introduction: Nonlinear mixed-effects models are fundamental to pharmacometrics, and the first-order conditional estimation with interaction (FOCE-I) method implemented in NONMEM[1]…
Read moreImproved Numerical Stability with Phoenix NLME (QRPEM) in a Complex Sequential PK/PD Modeling Workflow
Thursday 7 May, 2026
Overview: NONMEM has long been the industry standard for nonlinear mixed-effects (NLME) modeling, yet alternative platforms such as Phoenix NLME…
Read moreNew benchmarks for FOCE
Thursday 7 May, 2026
Introduction: The First-Order Conditional Estimation (FOCE) method remains central to the application of non-linear mixed-effects models in pharmacometrics. Datasets of…
Read moreDevelopment of averaged population pharmacokinetic model of vancomycin for paediatric patients using Bayesian model averaging approach
Thursday 7 May, 2026
Introduction: Vancomycin has been used as a first-line treatment against methicillin-resistant Staphylococcus aureus for over 60 years and is also…
Read moreChallenges in Generating a Ground Truth for Method Development in Model-Informed Precision Dosing
Thursday 7 May, 2026
Objectives: In Model-Informed Precision Dosing (MIPD), Bayesian hierarchical models utilize prior knowledge from clinical trials and real world data to…
Read moreMONTE CARLO EXPECTATION-MAXIMIZATION IN PUMAS: LEVERAGING SUFFICIENT STATISTICS FOR FLEXIBLE PHARMACOMETRIC ANALYSIS
Thursday 7 May, 2026
Introduction: Expectation-maximization (EM) algorithms are a well-established alternative to likelihood-approximation-based methods such as FOCE and the Laplace method for parameter…
Read moreInvestigating Interoccasion Variability and Estimation Methods
Thursday 16 October, 2025
Objectives: Interoccasion (IOV) variability, also known as the variability that accounts for the changes in individual pharmacokinetic (PK) parameters between…
Read moreIntegrating Python optimization algorithms inside PhysPK® (PK/PD/PBPK) software for improving PK estimation methods.
Thursday 16 October, 2025
Introduction/Objectives: Characterization of the pharmacokinetics (PK) and pharmacodynamics (PD) of a drug product through mathematical modelling approaches of the relationships…
Read moreComparison of performances of the open-source R package “nlmixr” vs. Monolix for population pharmacokinetics of continuous infusion meropenem in patients with onco-hematological malignancies
Thursday 16 October, 2025
Introduction Meropenem is a carbapenem used for empirical escalation therapy of onco-hematological patients with febrile neutropenia who are at risk…
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