Thursday 16 October, 2025
Objectives: MEDI7219 is a novel orally-delivered GLP-1 peptide receptor agonist (RA) developed for the type II diabetes indication and characterized…
Read morePoster: Methodology - Covariate/Variability Models
COSSAC (COnditional Sampling use for Stepwise Approach based on Correlation tests) method for covariate search
Thursday 16 October, 2025
Introduction/Objectives: Covariate search is a key element in the modeling process. As it involves a large number of runs, automatic covariate…
Read moreComparison of approaches for estimating covariate effects in full random effects models
Thursday 16 October, 2025
Objectives: The full random effects modeling (FREM) approach [1] has been developed for covariate model building in nonlinear mixed effects …
Read morePopulation pharmacokinetics of ciprofloxacin in critically ill patients-a covariate analysis
Thursday 16 October, 2025
Objective: For critically ill patients, physiological changes result in altered ciprofloxacin pharmacokinetics, possibly causing inadequate drug exposure. We aimed to…
Read moreOperating Characteristics of Stepwise Covariate Selection in Pharmacometric Modeling
Thursday 16 October, 2025
Objectives: Stepwise covariate modeling (SCM) is a widely used tool in pharmacometric analyses to identify covariates that explain source of variability…
Read moreChanges in liver volume – a population-based approach to meta-analysis of paediatric, adult and geriatric populations
Thursday 16 October, 2025
Objectives: Liver volume is a critical parameter for both donor / recipient graft size and as a scaling factor for…
Read moreNonparametric goodness-of-fit testing for parametric covariate models
Thursday 16 October, 2025
Objectives: Covariates allow to identify patient subpopulations at risk or to individualize drug treatment. While covariate selection criteria have been studied…
Read moreAn information-theoretic evaluation of vine copula models for high-dimensional covariate distributions
Thursday 16 October, 2025
Objectives: Statistical modelling of covariate distributions allows to create virtual populations or to impute missing values in a covariate dataset. However,…
Read moreAssessment of propensity score and Mahalanobis distance matching in mixed outcome data
Thursday 16 October, 2025
Objectives: Matching methodology in pharmacometrics has been used by the FDA [1] for determining drug effect in the presence of confounding variables. Common…
Read moreThe impact of unmodelled interoccasion variability in bioavailability and absorption on parameter estimates in population pharmacokinetic analysis
Thursday 16 October, 2025
Objectives: In their landmark paper Karlsson and Sheiner [1] showed that ignoring interoccasion variability in pharmacokinetic data can lead to…
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