Thursday 16 October, 2025
Objectives: The variability in patients’ therapeutic responses underscores the importance of understanding pharmacokinetics (PK) and pharmacodynamics (PD) for effective drug…
Read morePoster: Methodology - Covariate/Variability Models
Causal considerations in Exposure-Response and Population PK covariate analysis
Thursday 16 October, 2025
Background & Objectives: Pharmacometric models often address causal questions, specifically examining the impact of changing an independent variable (X) on…
Read moreCovariate Modelling and Bayesian Inference for Physiologically Based Pharmacokinetic Models
Thursday 16 October, 2025
Objectives: We describe a general framework for integrating data on individual-specific covariates (measurable physiological characteristics and other parameters dependent on those)…
Read morepmxcopula – R package for copula-based covariate simulation
Thursday 16 October, 2025
Introduction: Patient characteristics or covariates can inform treatment optimization using pharmacometric simulations. Incorporating realistic sets of patient covariates, i.e. virtual…
Read moreGeneration of realistic virtual adult populations using the NHANES database: a copula approach
Thursday 16 October, 2025
Introduction: Generation of virtual patient populations which consist of sets of patient-associated covariates is of relevance for pharmacometric simulations of…
Read moreComparison of PK models using normal and log-transformed scale data
Thursday 16 October, 2025
Introduction: Pharmacometric modelers usually choose on what form of data to use: normal scale or natural log-transformed data. While it is…
Read moreExtension of the covariate clinical relevance determination in population pharmacokinetic analyses to the Least Absolute Shrinkage and Selection Operator (LASSO) and to Genetic Algorithm (GA) approaches
Thursday 16 October, 2025
Introduction: Identifying covariate clinical relevance (CCR) is essential for patient dose adjustment and is a key step according to health…
Read moreA unifying approach to sampling NLME model parameters
Thursday 16 October, 2025
Objectives: Simulation of models is a key element of model diagnostics as well as a popular method for model-based prospective decision…
Read moreNew findings challenging common concepts on drug pharmacokinetics in the obese
Thursday 16 October, 2025
Objectives: Overweight and obesity is rising worldwide and pharmacotherapy of these patients is challenging. As the number of studies on…
Read moreStepwise Covariate Modelling (SCM) versus Full Random Effects Modelling (FREM) for covariate modelling of liver function markers exemplified with tigecycline
Thursday 16 October, 2025
Introduction/Objectives: The hepatic panel offers many potential covariates to inform about liver function, but no single biomarker can estimate the…
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