Thursday 16 October, 2025
Objectives: Tuberculosis meningitis (TBM) is a devastating manifestation of infection by Mycobacterium tuberculosis and is associated with severe morbidity and…
Read morePoster: Drug/Disease Modelling - Infection
Pemba Island, Tanzania, versus Côte d’Ivoire – Population effect on apparent clearance of active albendazole metabolites
Thursday 16 October, 2025
Objectives: Soil transmitted helminth infections affect an estimated 24% of the world’s population [1]. Communities with poor access to sanitation…
Read morePopulation pharmacokinetics and pharmacodynamics of eravacycline against pulmonary infections
Thursday 16 October, 2025
Introduction: Eravacycline is a broad-spectrum fluorocycline approved to treat complicated intra-abdominal infections. In lung-infected animal models, it was effective against…
Read morePopulation pharmacokinetic analysis of isoniazid in plasma and cerebrospinal fluid from adults with HIV-associated tuberculosis meningitis
Thursday 16 October, 2025
Objectives: Tuberculosis Meningitis (TBM) represents the most severe and incapacitating manifestation of infection by Mycobacterium tuberculosis, especially among individuals with…
Read morePopulation Pharmacokinetic Modelling of Twice Daily 50mg Dolutegravir in Children with Tuberculosis and HIV during Rifampicin Co-administration
Thursday 16 October, 2025
Introduction: The World Health Organization (WHO) recommends a dolutegravir-based regimen for first-line antiretroviral treatment (ART), with ART initiated during tuberculosis…
Read moreModel-based optimal dosing regimen for recombinant hepatitis B human immunoglobulin (GC1102) in Chronic Hepatitis B Patients
Thursday 16 October, 2025
Objectives: To propose a model-based optimal dosing regimen of recombinant hepatitis B human immunoglobulin based on phase 1 clinical data…
Read morePopulation pharmacokinetics of levofloxacin in South African adults treated for rifampicin-resistant tuberculosis.
Thursday 16 October, 2025
Objectives: Rifampicin-resistant TB (RR-TB) is a global public health concern. Incident cases increased globally by 3% from 2020 to 2021…
Read morePopulation pharmacokinetics of delamanid in adults treated for rifampicin-resistant tuberculosis: effect of pregnancy.
Thursday 16 October, 2025
Objectives: Delamanid is a WHO-recommended drug for the treatment of RR-TB [1]. Delamanid has a terminal half-life of 30-38 h…
Read morePopulation PK analysis of chloroquine in a humanized mouse model of P.falciparum malaria
Thursday 16 October, 2025
Objectives: Malaria is a life-threatening disease caused by protozoa of the genus Plasmodium which are spread to people through the…
Read moreA pharmacometric multistate model for analyzing long-term outcomes of patients with drug-resistant tuberculosis under bedaquiline treatment
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is one of the deadliest infectious diseases worldwide. Bedaquiline (BDQ), a drug used as part of combination…
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