Thursday 16 October, 2025
Introduction Antimicrobial resistance is a rapidly spreading threat to global public health. Efficient drug development is required to increase the…
Read morePoster: Drug/Disease Modelling - Infection
Model informed dose projection for SAB-176 using a joint time-to-event modeling approach in high-risk (HR) patients infected with Influenza
Thursday 16 October, 2025
Objectives: Influenza, a significant global health concern, can causes severe illness, hospitalizations, and death predominantly in high-risk (HR) groups, including…
Read moreFramework for Polyclonal Antibody Drug Development: Integrating Trial Data and Literature Models
Thursday 16 October, 2025
Objectives: In the pursuit of advancing immunotherapy for immune and autoimmune disorders, SAb has developed fully human, multi-targeted immunoglobulins (IgGs)…
Read moreBuilding a model from comparison of SARS-CoV-2 viral dynamics model proposed since 2020: what are the main differences?
Thursday 16 October, 2025
Introduction: Several mathematical models have been used to characterize viral kinetics of SARS-CoV-2 since 2020. While models may commence with…
Read moreModeling the influence of antiretroviral treatment initiation time on post-treatment control of HIV infection
Thursday 16 October, 2025
Objectives: The current standard of care for HIV infection involves antiretroviral therapy (ART) [1]. ART is not curative and treatment…
Read moreProtocol optimization for the evaluation of pharmacokinetics, biomarkers and efficacy of antitubercular drugs in a novel tuberculosis infection model in marmosets
Thursday 16 October, 2025
Objectives: The development of more efficacious drug regimens against M. tb requires predictive preclinical animal models encompassing the same pathological…
Read morePharmacometric modelling to describe pharmacokinetics and exposure-response of ivermectin in adolescent patients infected with Trichuris trichiura
Thursday 16 October, 2025
Introduction: Soil-transmitted helminth infections are a major public health challenge in many tropical and subtropical low-income regions. Monotherapy with albendazole…
Read moreQuantifying the impact of infection on murine antibiotic exposure in the framework of non-conventional treatment modalities within the FAIR study
Thursday 16 October, 2025
Introduction: Antibiotic resistance has been declared “one of the biggest threats to global health, food security, and development today” by…
Read moreDo critically ill patients undergoing continuous renal replacement therapy require ceftaroline dosage adjustments? Ceftaroline PopPK model and dosage simulations with probability of target attainment analysis based on retrospective data.
Thursday 16 October, 2025
Introduction/Objectives: Ceftaroline is a fifth-generation cephalosporin reserved for treating resistant gram-positive and gram-negative bacteria [1]. Currently, no dosing standards have…
Read moreAntibiotic pharmacokinetic modelling versus antibiotic therapy optimisation and resistance reduction: Bibliometric analysis
Thursday 16 October, 2025
Objectives: Modern statistics and pharmacokinetic (PK) modelling are increasingly applied to calculate personalised dosage regimens or estimate unique drug dosage…
Read more