Thursday 16 October, 2025
Objectives: Proteolysis-targeting chimeras (PROTAC) are novel chemical concepts taking advantage of the proteasome ubiquitination system to degrade the protein of…
Read morePoster: Drug/Disease Modelling - Infection
Semi-mechanistic population pharmacokinetic modelling of the novel antituberculosis drug TBAJ-876 and its metabolite M3 in healthy volunteers
Thursday 16 October, 2025
Objectives: TBAJ-876 is a novel second-generation oral diarylquinoline under development for the treatment of tuberculosis (TB). TBAJ-876 and its metabolite…
Read moreDo critically ill patients undergoing continuous renal replacement therapy require levofloxacin dosage adjustments? Levofloxacin PopPK model and dosage simulations based on retrospective data and developed using open-source R packages.
Thursday 16 October, 2025
Introduction/Objectives: Levofloxacin is a third-generation fluoroquinolone with a broad spectrum, including gram-positive and -negative bacteria [1]. Currently, no dosing standards…
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