Thursday 16 October, 2025
Background and Objectives: Bacteriophages, or phages, are viruses that infect and replicate within bacterial cells, ultimately leading to bacterial lysis….
Read morePoster: Drug/Disease Modelling - Infection
Predicting later-phase clinical trial efficacy in tuberculosis through back-translational modeling of rifapentine-containing regimens
Thursday 16 October, 2025
Introduction Effective treatment of tuberculosis requires the development of shorter and improved treatment regimens that increase efficacy and safety and…
Read moreViral kinetic modeling of mosnodenvir prophylaxis against DENV-3 in a controlled human infection model
Thursday 16 October, 2025
Introduction: Dengue virus (DENV) infection is transmitted to humans through the bite of infected mosquitoes and caused by any of…
Read moreJoint model for piperacillin and meropenem: assessing the impact of a joint pharmacokinetic modeling approach on covariate inclusion and probability of target attainment
Thursday 16 October, 2025
Introduction/Objectives: Beta-lactam antibiotics often share similar properties in terms of physicochemical, pharmacokinetic (PK) and pharmacodynamic properties. Piperacillin and meropenem are…
Read morePopulation Pharmacokinetic Model of Darunavir and Ritonavir in Pregnant and Postpartum Women with Human Immunodeficiency Virus Infection
Thursday 16 October, 2025
Introduction/ Objectives: Anatomical and physiological changes during pregnancy, including alterations in the function of proteins such as plasma proteins or…
Read morePopulation Pharmacokinetic Analysis of Lenacapavir in People Who Want or Need Pre-Exposure Prophylaxis
Thursday 16 October, 2025
Introduction: Lenacapavir (LEN) is a first-in-class HIV-1 capsid inhibitor administered as a twice-yearly subcutaneous (SC) injection for HIV-1 prevention. In…
Read moreA pharmacokinetics–time to alleviation of symptoms model to support extrapolation of baloxavir marboxil efficacy in pediatric patients with influenza
Thursday 16 October, 2025
Objectives: Baloxavir marboxil (Bxm) is an antiviral prodrug that is converted by hydrolysis to the active form baloxavir acid (here…
Read moreA model-based approach for the characterisation of anti-tubercular effects of BPaL combination therapy in an in vitro time-kill assay
Thursday 16 October, 2025
Introduction The persistent occurrence of Mycobacterium tuberculosis (Mtb) strains showing low susceptibility or resistance to some or all available antibiotics…
Read moreBeyond the RSE: Improving accuracy of in-host population modeling
Thursday 16 October, 2025
Introduction: Reliable parameter estimation for in-host models is based on understanding the interplay between the data quality and model complexity,…
Read morePharmacokinetics of the antimalarial drug pyronaridine: impact of pregnancy, malaria infection and HIV co-infection
Thursday 16 October, 2025
Introduction Pregnant women are highly vulnerable to malaria, yet concerns over safety often exclude them from clinical trials, limiting treatment…
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