Thursday 16 October, 2025
Objectives: Voriconazole, a first-line anti-fungal therapy, exhibits nonlinear pharmacokinetics together with large inter-individual variability but has a narrow therapeutic range….
Read morePoster: Drug/Disease Modelling - Infection
Exploring Standard and Alternative Darunavir/Ritonavir Dosing Regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modeling
Thursday 16 October, 2025
Objectives: Darunavir is administered as 800 mg once (QD) or 600 mg twice (BID) daily in combination with low-dose (100…
Read morePopulation Pharmacokinetics of Micafungin in critically ill patients – evaluation of a fixed dose regimen
Thursday 16 October, 2025
Objectives: For the treatment of invasive fungal infections (IFIs) micafungin is usually applied with a fixed dose of 100 mg for…
Read moreNonparametric Pharmacokinetic-Pharmacodynamic Modelling of Posaconazole
Thursday 16 October, 2025
Objectives: As one of the latest triazole antifungal agents Posaconazole shows activity against both Aspergillus spp. and Candida spp. [1]. Posaconazole…
Read moreModeling viral kinetics predicts a rapid establishment of the cytotoxic immune response targeting distinct infected cell compartments in SIV controller macaques (ANRS SIC study)
Thursday 16 October, 2025
Objectives: Our group recently demonstrated that long term control of SIV infection can be obtained in cynomolgus macaques presenting a…
Read moreModelling Cytomegalovirus Growth Kinetics in Immunocompromised Children
Thursday 16 October, 2025
Objectives: To produce a three compartment cytomegalovirus (CMV) viral kinetic (VK) model that is able to accurately predict viral loads…
Read moreTigecycline population pharmacokinetics in patients with severe sepsis or septic shock resulting from abdominal surgery
Thursday 16 October, 2025
Objectives: Tigecycline is the first glycylcycline antimicrobial drug approved in Europe for the treatment of complicated skin and skin structure…
Read moreQuantifying adaptive resistance in bacteria using well-designed dynamic time-kill curve experiments
Thursday 16 October, 2025
Objectives: In vitro time-kill curve (TKC) experiments allow to study the dose-effect relationship of antimicrobial treatments, either in a static…
Read moreIs a pooled population pharmacokinetic model predictive of plasma and microdialysate pharmacokinetics of linezolid in obese and non-obese patients?
Thursday 16 October, 2025
Objectives: Linezolid (LZD) is an oxazolidinone antibiotic exhibiting wide activity against gram-positive pathogens. Antibiotic concentrations at the site of infection are…
Read moreMultiscale, mechanistic pipeline to assess the prophylactic efficacy of anti- HIV compounds
Thursday 16 October, 2025
Objectives: While HIV-1 cannot be cured to date, pre-exposure prophylaxis (PrEP) has been suggested to halt the ongoing spread of HIV…
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