Thursday 16 October, 2025
Objectives: Rifamycins play a key role in the multidrug treatment of tuberculosis. With its long half-life and excellent sterilizing activity,…
Read morePoster: Drug/Disease Modelling - Infection
A semi-mechanistic model to characterise the influence of nevirapine- and lopinavir/ritonavir-based therapy on artemether and dihydroartemisinin exposure
Thursday 16 October, 2025
Objectives: Artemether-lumefantrine is the most widely recommended first-line treatment for uncomplicated falciparum malaria globally. Considering the substantial geographic overlap of…
Read moreDo differences in PK defeat similarities in immune system in non-human primates? Pharmacokinetic modelling of standard of care antitubercular drugs in marmosets
Thursday 16 October, 2025
Objectives: the antitubercular drug development process requires the use of animals mimicking the complex pathophysiology occurring in humans [1]. Several…
Read moreAntitubercular effects of TBAJ-587 a new diarylquinoline derivative on sub-populations of M. tuberculosis and prediction of early bactericidal activity in humans
Thursday 16 October, 2025
Introduction: Tuberculosis (TB) is a complex disease in which the heterogeneity of pathological lesions, and the presence bacterial phenotypes with…
Read moreUtilizing the AZD7442 Model for Accelerated New Drug Development: Pharmacokinetic Insights Across Infectious Disease Prevention and Passive Immunization
Thursday 16 October, 2025
Introduction: Due to the coronavirus disease 2019 (COVID-19) pandemic and the rise of drug-resistant bacteria, the rapid development of neutralizing…
Read morePopulation pharmacokinetic analysis of intravenous telavancin in healthy subjects undergoing plasma and tissue microdialysis
Thursday 16 October, 2025
Objectives: Telavancin is a novel lipoglycoprotein used to treat complicated skin and soft tissue infections and hospital acquired pneumonia with MRSA….
Read morePopulation pharmacokinetic analysis of piperacillin in acute haemorrhagic stroke patients – a cerebral microdialysis study
Thursday 16 October, 2025
Objectives: Piperacillin is an extended-spectrum penicillin antibiotic with excellent activity against Gram-positive and -negative bacteria and is thus frequently used…
Read morePopulation pharmacokinetics of cefepime in critically ill patients with and without impaired renal function
Thursday 16 October, 2025
Introduction Pathophysiological changes in ICU patients with severe infections lead to a high pharmacokinetic variability (1) and risk of improper…
Read moreJoint modeling of moxifloxacin pharmacokinetics and fecal microbiota disruption in healthy volunteers
Thursday 16 October, 2025
Objectives: Metagenomic analysis provides a detailed picture of the intestinal microbiota. Among the various factors that shape the microbiota, antibiotic…
Read moreDosing of convalescent plasma and hyperimmune anti-SARS-CoV-2 immunoglobulins: a phase I/II dose finding study
Thursday 16 October, 2025
Introduction: During the COVID-19 pandemic, trials on convalescent plasma (ConvP) and hyperimmune globulins (COVIg) were performed without preceding dose-finding studies.[1,2]…
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