Thursday 16 October, 2025
Objectives: Echinocandins are first-line agents to treat invasive candidiasis. However, resistance to these drugs is increasing. As pharmacokinetic/pharmacodynamic (PK/PD) modelling of…
Read morePoster: Drug/Disease Modelling - Infection
Pharmacodynamic modelling to evaluate the in vitro activity of amphotericin B against Candida auris
Thursday 16 October, 2025
Objectives: Candida auris is an emerging multidrug-resistant yeast that causes invasive candidiasis. It is associated with high mortality rates, up…
Read morePharmacokinetic/pharmacodynamic modelling and simulation of the in vitro activity of isavuconazole and echinocandin combination against Candida auris.
Thursday 16 October, 2025
Objectives: Candida auris is a multi-drug resistant fungal pathogen responsible for several cases of invasive fungaemia since 2009. Echinocandins are…
Read moreEvaluating potential link between liver enzyme abnormalities and bedaquiline exposure in multi-drug resistant tuberculosis patients
Thursday 16 October, 2025
Objectives: Bedaquiline (BDQ) is a drug indicated in the treatment of multidrug-resistant (MDR) tuberculosis (TB) as part of combination therapy [1]….
Read moreModel-Informed selection of doses and sample size for a Phase 2a POC study of GSK3640254, a next generation HIV-1 maturation inhibitor
Thursday 16 October, 2025
Introduction: GSK3640254 (MI-254) is a next generation HIV maturation inhibitor (MI) that prevents maturation of HIV-1 virions by binding near…
Read moreA population pharmacokinetic analysis of voriconazole according to CYP2C19 phenotype in healthy subjects and patients
Thursday 16 October, 2025
Introduction: Voriconazole is a broad-spectrum antifungal agent for the treatment of invasive aspergillosis. High variable and non-linear pharmacokinetics of voriconazole…
Read morePopulation pharmacokinetics of delamanid and its main metabolite DM-6705 in patients with multidrug resistant tuberculosis
Thursday 16 October, 2025
Objectives: With approximately 10 million new cases and 1.4 million related deaths reported in 2019, tuberculosis (TB) was the most…
Read moreBedaquiline’s exposure-response relationship evaluated with data from the observational study C209
Thursday 16 October, 2025
Objectives: To confirm a previously characterized relationship between bedaquiline (BDQ) exposure and the decline of mycobacterial load (MBL) during treatment of…
Read moreJoint model for the characterisation of cefuroxime pharmacokinetics in synovial fluid, interstitial fluid of muscle tissue and plasma
Thursday 16 October, 2025
Objectives: Cefuroxime, a broad-spectrum cephalosporin antibiotic, is routinely administered as preoperative prophylaxis during orthopaedic surgery and for the treatment of…
Read morePopulation pharmacokinetic characterisation of plasma-to-breast milk transfer of lamivudine and subsequent infant exposure through breast milk
Thursday 16 October, 2025
Introduction Lamivudine (3TC) is a component of several firstline antiretroviral (ARV) regimens used to treat HIV and is a WHO-listed…
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