Thursday 16 October, 2025
Objectives: To develop a nonlinear pharmacokinetic (PK) model that characterizes the exposures of ALS-033719 and ALS‑033927, the active moiety and metabolite,…
Read morePoster: Drug/Disease Modelling - Infection
Pharmacokinetics of isoniazid preventative therapy among HIV-infected pregnant women in high tuberculosis incidence settings
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) predominantly affects women of reproductive age and pregnant women are at elevated risk of progression from latent…
Read morePharmacokinetics of high dose isoniazid among individuals with multidrug-resistant tuberculosis
Thursday 16 October, 2025
Objectives: High dose isoniazid has been reported to be effective against tuberculosis with low to moderate isoniazid resistance (1). The shorter-course…
Read moreBactericidal activity of pretomanid against drug-sensitive tuberculosis in the presence of rifamycins
Thursday 16 October, 2025
Objectives: One of the challenges in tuberculosis (TB) control is the long duration of the treatment regimen(1). Drug-sensitive TB usually…
Read moreHuman Population PK Model, Dose Selection and Target Attainment Simulations for CF-301 – a Novel Antibacterial Lysin
Thursday 16 October, 2025
Introduction: CF-301, a novel bacteriophage-derived lysin that has completed the first Phase 1 trial in the US, is being developed…
Read moreEffect of pregnancy on raltegravir free concentrations
Thursday 16 October, 2025
Objectives: Raltegravir can be used for the prevention of mother-to-child HIV transmission, especially when a rapid decline of HIV RNA…
Read morePopulation pharmacokinetics of gentamycin in hospitalized ICU patients
Thursday 16 October, 2025
Objectives: To develop a PopPK model of gentamycin in ICU patients with either obesity, sepsis or acute respiratory distress syndrome,…
Read moreInforming BOHEMIA cluster randomized controlled trial ivermectin dose selection in healthy participants in Kenya
Thursday 16 October, 2025
ObjectivesA promising new strategy in malaria prevention is vector control through mass drug administration (MDA) of ivermectin, a broad-spectrum endectocide…
Read morePopulation Pharmacokinetic/Pharmacodynamic of a Toll-Like-Receptor 7 (TLR7) Agonist that Induces IP-10 and ISG15 in Cynomolgus Monkeys
Thursday 16 October, 2025
Objectives: TLR7 agonists stimulate the innate immunity by inducing cytokines and interferon-stimulated genes (ISGs) to trigger an antiviral or antitumor effect….
Read morePopulation pharmacokinetics and generation of dosing nomograms of daptomycin at a Swiss university hospital
Thursday 16 October, 2025
Introduction The lipopeptide antibiotic daptomycin is primarily used in the treatment of systemic infections with gram-positive bacteria, usually administered as…
Read more