Thursday 16 October, 2025
Objectives: Fremanezumab, a fully-humanized monoclonal antibody (IgG2Δa) that selectively targets calcitonin gene-related peptide, was found to be effective and well-tolerated as…
Read morePoster: Drug/Disease Modelling - CNS
Pharmacokinetic Profile of Sultiame in Healthy Volunteers with In Vitro Characterization of Its Uptake by Red Blood Cells
Thursday 16 October, 2025
Objectives: Sultiame (Ospolot®), an inhibitor of carbonic anhydrase, is a first choice treatment in selected countries for benign epilepsy with…
Read morePrediction and validation of antisense oligonucleotide distribution in human central nervous system
Thursday 16 October, 2025
Objectives To develop a physiologically-based pharmacokinetic (PBPK) model of intrathecal (IT) administration and distribution of antisense oligonucleotides (ASOs) in human…
Read morePharmacokinetics of dexmedetomidine in elderly patients undergoing sedation after abdominal aortic surgery.
Thursday 16 October, 2025
Objectives: Dexmedetomidine (DEX) is an α2-agonist which has been increasingly used for analgosedation. The aim of this study was to characterize…
Read moreQuantitative Predictive Models for the Degree of Disability After Acute Ischemic Stroke
Thursday 16 October, 2025
Objectives: Stroke is one of the most common causes of disability worldwide. The levels of disability and handicap among the survivors…
Read moreA population pharmacodynamic model of combination antidepressant therapy in depression
Thursday 16 October, 2025
Introduction: We believe only few population pharmacodynamic models have been developed regarding clinical effects of an antidepressant. Moreover, in real clinical…
Read moreA Model Based Meta-Analysis (MBMA) to support development of medicines for treatment of DPN, PHN and Fibromyalgia.
Thursday 16 October, 2025
Objectives: The objective of the analysis was to develop a MBMA comparator model for neuropathic pain to provide a quantitative…
Read morePersonalised delivery rate computation for intravenously administered anesthetic using Kalman filter
Thursday 16 October, 2025
Objectives: The controlled delivery of intravenous (IV) anesthetic, such as propofol, aims at fast and safe achievement and maintenance of…
Read moreApplication of pharmacometrics to stimulus response models to describe signalling profiles of the cannabinoid-1 receptor
Thursday 16 October, 2025
Objectives: Cannabinoid type 1 (CB1) receptor is G-protein coupled receptor (GPCR) present at high levels throughout the CNS [1]. CB1…
Read moreClinical validation of a quantitative systems pharmacology (QSP) model for nerve-growth-factor (NGF) therapies
Thursday 16 October, 2025
Objectives: Despite a marked increase in the application of quantitative systems pharmacology (QSP), its role in drug development and regulatory…
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