Thursday 16 October, 2025
Introduction/Objectives: Viral encephalitis is a rare but life-threatening central nervous system (CNS) infection commonly caused by herpesviruses with a mortality rate…
Read morePoster: Drug/Disease Modelling - CNS
Integrated Population PK and PBPK Modelling Approaches of IAMA-6 Plasma Concentrations following Oral, Intraperitoneal and Intravenous Administrations in Three Different Preclinical Species for First in Human Dose Prediction
Thursday 16 October, 2025
Introduction/Objectives: IAMA-6 is a small molecule, selective inhibitor of the sodium potassium chloride cotransporter (NKCC1), showing encouraging in vitro and in vivo…
Read moreA population pharmacokinetic model of N,N-dimethyltryptamine administered through continuous intravenous infusion in healthy smokers and non-smokers
Thursday 16 October, 2025
Introduction: Psychedelic agents such as N,N-dimethyltryptamine (DMT) are currently being studied for the treatment of various mental disorders [1][2]. To…
Read moreExposure-Response Analysis of Centanafadine Sustained Release Tablets in Adults with Attention-Deficit/Hyperactivity Disorder
Thursday 16 October, 2025
Objectives: Centanafadine is a small-molecule with inhibitory activity at norepinephrine, dopamine, and serotonin reuptake transporters and is under development for…
Read moreExploring the contribution of brain metabolism in mechanistic understanding of Kp,uu,BBB – A case study for remoxipride
Thursday 16 October, 2025
Objectives: Kp,uu,BBB values are crucial indicators of drug distribution into the brain, representing the steady-state relationship between unbound concentrations in…
Read moreNatural disease progression model with transition probabilities to describes the continuum of Alzheimer’s disease
Thursday 16 October, 2025
Introduction and objectives Understanding the natural Alzheimer`s Disease (AD) progression is important for developing disease modifying therapies [1]. Limited knowledge…
Read morePopulation pharmacokinetics of olanzapine and quetiapine in critically ill adults with delirium
Thursday 16 October, 2025
Introduction: The optimal drug and dosage for treating acute delirium lack consensus, especially among critically ill patients whose altered pharmacokinetics…
Read moreAn Exploratory Analysis of the Performance of Methylphenidate Regimens Based on a PKPD Model of Dopamine and Norepinephrine Transporter Occupancy
Thursday 16 October, 2025
Introduction: Methylphenidate (MPH) is a psychostimulant which inhibits the uptake of dopamine and norepinephrine transporters, DAT and NET, and is…
Read moreDonepezil brain and blood pharmacokinetic modeling after nasal film and oral solution administration in mice
Thursday 16 October, 2025
Introduction: The pharmacokinetic (PK) model development for nasal delivery is a challenging process without adequate literature reports. Intravenous PK models…
Read moreOptimizing infusion rates for N,N-dimethyltryptamine based on either a continuous variable model or a bounded integer model
Thursday 16 October, 2025
Introduction/Objectives: N,N-dimethyltryptamine (DMT) is a psychedelic compound that is currently being studied as a treatment option in a number of…
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