Thursday 16 October, 2025
Objectives: Lacosamide is an antiepileptic drug prescribed intravenously or orally for the treatment of partial seizures with or without secondary…
Read morePoster: Drug/Disease Modelling - CNS
PK/PD modelling of the effect of nanoencapsulated quetiapine on cortical dopamine concentrations in schizophrenia phenotyped rats
Thursday 16 October, 2025
Introduction: Schizophrenia (SCZ) is a chronic mental disorder associated with a dysregulation in brain dopaminergic system[1]. Quetiapine (QTP) is an…
Read moreEquivalent dose prediction of donepezil patch using population pharmacokinetic oral and patch combination model
Thursday 16 October, 2025
Objectives: Donepezil, a reversible inhibitor of the acetylcholinesterase enzyme, is used to treat mild-to-moderate and severe Alzheimer’s disease (AD). Despite…
Read moreOpioids distribution in human CNS might be altered due to pain-related increase of BBB permeability.
Thursday 16 October, 2025
Objectives: Chronic pain is an undesirable condition with drug treatments being mainly ineffective and are often associated with adverse effects….
Read moreMu-opioid receptor binding of morphine and its main metabolites: impact of non-linear BBB transport of morphine.
Thursday 16 October, 2025
Introduction: Chronic pain is a difficult disease, due to the complexity of neuronal plasticity [1,2], and many other factors involved….
Read moreQuantitative comparisons of Progressive Supranuclear Palsy rating scales versions using Item Response Theory modeling
Thursday 16 October, 2025
Background: Progressive Supranuclear Palsy (PSP) is a neurodegenerative late-onset disease that is challenging in terms of assessment. The Progressive Supranuclear…
Read morePopulation pharmacokinetic/pharmacodynamic modelling of the psychedelic experience induced by N,N-dimethyltryptamine
Thursday 16 October, 2025
Introduction/Objectives: N,N-dimethyltryptamine (DMT) is a naturally occurring, psychedelic compound that is believed to have potential as a treatment option in…
Read moreEvaluation of the pharmacokinetics of tideglusib in congenital and childhood myotonic dystrophy type 1 using Bayesian priors
Thursday 16 October, 2025
Introduction: GSK3β is an intracellular regulatory kinase that is dysregulated in multiple tissues in Type 1 myotonic dystrophy (DM-1), a rare…
Read moreA Bounded Integer Approach to Evaluate AIMS Score for Austedo in Patients with Tardive Dyskinesia
Thursday 16 October, 2025
Objectives: Tardive dyskinesia (TD) is a serious movement disorder that appears as a complication of the prolonged use of dopamine…
Read morePK-PD model of morphine, pregabalin and their combination to assess the opioid-sparing effect
Thursday 16 October, 2025
Introduction: Chronic pain (CP) causes major discomfort and is highly prevalent [1]. Opioids are currently the most effective class of…
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