Poster: Drug/Disease Modelling - CNS

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NfL concentration in CSF is a quantitative marker of the rate of neurodegeneration in aging and Huntington’s disease: a semi-mechanistic model-based analysis.

Thursday 16 October, 2025

Introduction and Objectives: Neurofilament light chain (NfL) is a structural protein of the neuronal cytoskeleton that is released into the…

Predicting Clinical Efficacy Endpoints of a Nipocalimab Phase 3 Study with a Population PKPD Model Developed with Data from a Phase 2 Study in Generalized Myasthenia Gravis

Thursday 16 October, 2025

Background: Generalized myasthenia gravis (gMG) is a rare, chronic, neuromuscular disease caused by pathogenic autoantibodies that impair or prevent muscle…