Thursday 16 October, 2025
Objectives: The objective of the present work was to develop a mechanism-based model that can predict the in vivo pharmacokinetic…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Extrapolation of lung pharmacokinetics of antitubercular drugs from preclinical species to humans using PBPK modeling
Thursday 16 October, 2025
Introduction Drugs against pulmonary tuberculosis (TB) need to be transported from the blood to the lung of TB patients and…
Read morePBBM of ibuprofen enantiomers in tablets: in silico exploration of bioequivalence studies design
Thursday 16 October, 2025
Introduction: Physiologically-based pharmacokinetic (PBPK) modelling has recently shown powerful prediction capabilities for drug exposure in humans and other species. However,…
Read morePharmacokinetic Modeling of Ticagrelor in the Presence of Morphine in Healthy Volunteers
Thursday 16 October, 2025
Objectives: Ticagrelor is a P2Y12 receptor antagonist used to prevent thrombotic events in patients with acute coronary syndromes. Morphine, commonly…
Read moreModel-based exploration of the P-glycoprotein concentration-activity relationship shows a drug and system dependency: implications for mechanistic PBPK modelling of active transporter activity
Thursday 16 October, 2025
Objectives Active transporters like P-glycoprotein (P-gp) expressed at the Blood-Brain-Border (BBB) limit the distribution of drugs to the central nervous…
Read moreAnalysis of the absorption processes using the top-down PBFTPK models Impact on the bottom up PBPK modeling work
Thursday 16 October, 2025
Introduction: The introduction of the Finite Absorption Time (F.A.T.) [1,2] concept led to the development of PBFTPK models [3-6]. These…
Read moreFTPK (Finite Time Pharmacokinetic) software for the analysis of pharmacokinetic data
Thursday 16 October, 2025
Introduction: The concept of finite absorption time (F.A.T.) has led to the development of physiologically based finite time pharmacokinetic (PBFTPK)…
Read moreA Physiologically-Based Computational Model of Bilirubin Metabolism: Integrating Real-World Data for Enhanced Clinical Evidence
Thursday 16 October, 2025
Introduction: Bilirubin plays a crucial role in the body’s elimination of hemoglobin and heme-containing proteins. Following its initial synthesis in…
Read moreA Phisiological-Based Pharmacokinetic model for CD25 Regulatory T cells targeted nanoparticles
Thursday 16 October, 2025
Introduction: Although immunotherapy (IT) has transformed cancer treatment, tumors can evade immunosurveillance by inducing infiltration of immune cells such as…
Read moreA Physiologically Based Pharmacokinetic Model of 89Zr-adalimumab in Healthy and Uveitis Diseased Rats
Thursday 16 October, 2025
Introduction. As the incidence and prevalence of eye diseases is expected to increase, the optimisation of dosing strategies and the…
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