Thursday 16 October, 2025
Introduction: Contemporary antiretrovirals (ARVs) have a lower propensity to cause drug-drug interactions (DDIs), however they can be subject to DDIs…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Nintedanib physiologically based pharmacokinetic (PBPK) model to predict drug-drug interactions
Thursday 16 October, 2025
Background and objectives: Nintedanib is a narrow therapy index drug and an essential co-medication to treat idiopathic pulmonary fibrosis (IPF). It…
Read moreDevelopment of a physiologically based pharmacokinetic model of Ciprofloxacin in ovine septic shock
Thursday 16 October, 2025
Objectives: Sepsis is defined as fatal organ dysfunction caused by a dysregulated host response to infection and is associated with…
Read moreImplementation of Oral Drug Absorption in Older Adults in the Physiologically Based Pharmacokinetic (PBPK) Modelling Platforms
Thursday 16 October, 2025
Objectives: The older population consisting of persons aged 65 years or older is the fastest-growing population group and also the…
Read moreElucidating parametric first and second-order effects in PBPK models for special scenarios using a GSA-based approach
Thursday 16 October, 2025
Objectives: Physiological based pharmacokinetic (PBPK) models are convoluted systems with many non-linear or interacting parameters, which can lead to high…
Read morePrediction of gastric pH-mediated drug exposure changes using physiologically based pharmacokinetic modeling: A case study of itraconazole
Thursday 16 October, 2025
Objectives: Abnormal gastric acidity including achlorhydria can act as a significant source of variability in the absorption of drugs especially…
Read moreDose Adaptations for Drug-Gene and Drug-Drug Interactions involving Clopidogrel – A Physiologically based Pharmacokinetic (PBPK) Modeling Approach
Thursday 16 October, 2025
Introduction: The antiplatelet agent clopidogrel is widely used for the prevention of atherothrombotic events [1]. Clopidogrel’s active metabolite (Clo-AM) is…
Read morePhysiologically Based Pharmacokinetic Modeling of Imatinib and Its Main Metabolite for Drug–Drug Interaction Predictions
Thursday 16 October, 2025
Introduction: Since its approval in 2001, the tyrosine kinase inhibitor imatinib has revolutionized the development of targeted cancer therapy and,…
Read moreUnraveling the CYP2D6 Drug-Drug-Gene Interaction Network: A Comprehensive PBPK Analysis of Key Substrates and Inhibitors
Thursday 16 October, 2025
Introduction: Drug-drug interactions (DDIs) and drug-gene interactions (DGIs) are key drivers of adverse drug reactions [1], posing substantial challenges in…
Read morePhysiologically-Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to Sildenafil and Bosentan: a contribution from the ConcePTION Project
Thursday 16 October, 2025
Objectives: Sildenafil and bosentan are used as combined therapy for pulmonary arterial hypertension (PAH). Since pregnancy is contra-indicated for women…
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