Thursday 16 October, 2025
Objectives: To use population PK modeling to characterize the effect of Japanese ethnicity on the non-linear plasma pharmacokinetics of grazoprevir,…
Read morePoster: Drug/Disease modeling - Other topics
Modeling the effect of ranibizumab on central retinal thickness in patients with wet age-related macular degeneration
Thursday 16 October, 2025
Objectives: The progression of the wet form of age-related macular degeneration (wet AMD) and the effect of the anti-VEGF ranibizumab on…
Read morePopulation PK modeling of RPH-104, novel optimized IL-1 beta trap, and assessment of the immunogenicity effect on pharmacokinetics
Thursday 16 October, 2025
Objectives: RPH-104 (JSC R-Pharm) is a novel heterodimeric fusion protein, capable of inhibition of human IL-1 beta/IL-1F2 signaling pathway, for the…
Read moreTarget evaluation for Inflammatory Bowel Disease (IBD) using a Systems Pharmacology model
Thursday 16 October, 2025
Objectives: To develop a Systems Pharmacology (SP) model for IBD able to evaluate therapeutic targets for different types of IBD patients,…
Read moreA target mediated cellular uptake model to assess the asialogycoprotein receptor shuttle capacity in hepatocytes
Thursday 16 October, 2025
Objectives: GalNAc, triantennary N-acetyl galactosamine, is a high-affinity ligand to the asialoglycoproteins receptor (ASGPR) which is highly expressed at the hepatocyte…
Read moreModeling Duchenne muscular dystrophy disease progression as assessed by the 6-minute walk test
Thursday 16 October, 2025
Objectives: To build a disease progression model of Duchenne muscular dystrophy (DMD), a rare disease, given public source 6-minute walk test…
Read morePharmacokinetic and Pharmacodynamic Modeling of Alirocumab and Evolocumab, two fully human monoclonal antibodies targeting PCSK9
Thursday 16 October, 2025
Objectives: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a soluble protein that enhances low density lipoprotein cholesterol (LDLc) receptor degradation…
Read morePharmacokinetic and Pharmacodynamic Modeling of Acetylsalicylic Acid and its Major Metabolite Salicylic Acid
Thursday 16 October, 2025
Objectives: Acetylsalicylic acid (ASA) is a well-known antipyretic drug and has been studied and used for its anti-thrombotic effect since…
Read moreFirst population pharmacokinetic model of lidocaine tumescent anaesthesia in women undergoing breast cancer surgery
Thursday 16 October, 2025
Objectives: In breast cancer, tumescent lidocaine anaesthesia could increase accessibility to mastectomy in elderly women with comorbidities and relieve post-operative pain….
Read moreTranslating Pharmacogenomics for Personalised Medicine
Thursday 16 October, 2025
Objectives: To develop an integrated electronic Pharmacogenomics (PGx) web service that provides personalized genotype-to-phenotype translation services, linked to drug recommendations. Methods: Genomic…
Read more