Thursday 16 October, 2025
Objectives: Recent studies have shown that intravitreal or intracameral injection of bevacizumab, a full length anti-VEGF antibody, may be a…
Read morePoster: Drug/Disease modeling - Other topics
BayesDB Marcro Indicator Explorer ensemble models for growth outcome country phenotyping
Thursday 16 October, 2025
Objectives: To make it possible for non-technical HBGD stakeholders to ask and answer empirical questions, such as “What countries are probably…
Read moreCompetitive brain and body growth model
Thursday 16 October, 2025
Background: Malnutrition has a considerable effect on the body development during childhood and, in particular, it affects brain development and…
Read moreDose estimation based on population pharmacokinetic/pharmacogenetic modeling for enteric-coated mycophenolate sodium in kidney transplant recipients
Thursday 16 October, 2025
Objectives: Enteric-coated mycophenolate sodium (EC-MPS) is effective and safe in preventing rejection after transplantation and is mainly transported by ABCs and…
Read moreTheory based PK-PD of S- and R-warfarin: influence of body size, composition and genotype
Thursday 16 October, 2025
Objectives: 1) Apply a theory based mechanistic model to describe the PK and PD of S- and R-warfarin [1] 2) To explore…
Read morePharmacokinetic characterization of naphtalophos in lambs by modelling blood acetylcholinesterase activity, a K-PD model
Thursday 16 October, 2025
Objectives: Naphthalophos (NAF) is a widely used organophosphate for the control of sheep gastrointestinal nematode infection. In this work, a…
Read moreA population pharmacokinetic-pharmacodynamic model for AZD7687: Effects on plasma triacylglycerol after oral lipid tolerance test
Thursday 16 October, 2025
Objectives: Measuring plasma triglyceride (TAG) by means of an Oral-Lipid-Tolerance-Test (OLTT) can determine the efficiency with which the individual uses…
Read moreA systems pharmacology model of SGLT2 and SGLT1 inhibition to understand mechanism and quantification of urinary glucose excretion after treatment with Dapagliflozin, Canagliflozin and Empagliflozin
Thursday 16 October, 2025
Objectives: Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors are a class of drugs effective for type 2 diabetes treatment [1]. However, given…
Read moreA mechanistic PKPD model relating early asthmatic response to anti-leukotriene drug PK and biomarker levels in allergen challenge studies
Thursday 16 October, 2025
Objectives: Inhibition of leukotriene (LT) production in asthmatic patients attenuates the drop in Forced Expiratory Volume in 1 second (FEV1) after…
Read moreModel-based dose selection of tocilizumab for the prevention of reperfusion injury.
Thursday 16 October, 2025
Objectives: Whereas moderate C-reactive protein (CRP) elevation in the general population is linked to long-term risk of coronary heart disease, an…
Read more