Thursday 16 October, 2025
Objectives: Intravenous ketamine, though effective for pediatric sedation, poses logistical challenges and patient distress. Intranasal administration offers a noninvasive alternative…
Read morePoster: Clinical Applications
Exploring the impact of clinical covariates on predictive performance of vancomycin population pharmacokinetic modeling in patients receiving high flux intermittent hemodialysis
Thursday 16 October, 2025
Introduction: Intravenous (IV) vancomycin remains a cornerstone of antimicrobial therapy for patients undergoing chronic hemodialysis (HD), given the increased risk…
Read moreA review on the role of extrapolation as basis for paediatric marketing authorization applications of medicines in the EU
Thursday 16 October, 2025
Introduction For new medicines, drug companies obtain regulatory approval on the strategy to generate sufficient evidence to support the benefit/risk…
Read morePharmacokinetic optimization of valganciclovir and ganciclovir therapy in lung transplant recipients
Thursday 16 October, 2025
Introduction/objectives: Intravenous ganciclovir (GCV) and its oral prodrug valganciclovir (VGCV) are gold standard treatments for both prevention and treatment of…
Read moreImproving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients
Thursday 16 October, 2025
Introduction: Salbutamol, a short-acting ß2-agonist widely used in asthma treatment [1], is available in multiple formulations, including inhalers, nebulizers, oral…
Read moreNipocalimab Effect on IgG Subclasses in Patients with Generalized Myasthenia Gravis (gMG)
Thursday 16 October, 2025
Background and Objectives: Nipocalimab, a fully human IgG1 monoclonal antibody, binds selectively and with high affinity to FcRn, which inhibits…
Read moreModel-averaging, but not flattened priors, benefitted to the model-informed precision dosing of oral kinase inhibitors in oncology
Thursday 16 October, 2025
Introduction Conventional therapeutic drug monitoring (TDM) of oral kinase inhibitors consists in comparing a concentration, measured exactly at the time…
Read moreA Bayesian-NLME approach identifies patients at risk of delayed MTX elimination if informative TDM data is provided
Thursday 16 October, 2025
Introduction Physicians must constantly assess treatment-related risks based on limited data. This is particularly difficult in oncology, as compounds often…
Read moreRelationship between factor IX activity levels and bleeding in patients with haemophilia B on prophylaxis with an extended half-life factor IX concentrate (rIX-FP): A repeated time-to-event analysis.
Thursday 16 October, 2025
Introduction: In haemophilia B patients on prophylaxis with an extended half-life factor IX (EHL-FIX) concentrate, pharmacokinetic (PK)-guided dosing can be…
Read morePopulation pharmacokinetic modelling of amoxicillin concentrations in human breast milk – a contribution from the ConcePTION project
Thursday 16 October, 2025
Introduction Amoxicillin, a widely used ß-lactam antibiotic, requires better pharmacokinetic characterization during breastfeeding. Few studies have assessed the risks associated…
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