Thursday 16 October, 2025
Objective: Previously we have developed a population pharmacokinetic (PK) model for methotrexate (MTX) in breast cancer patients [1]. This model…
Read morePoster: Applications- Oncology
Cyclophosphamide, Methotrexate, and 5-Fluorouracil Population Pharmacokinetic Models with Pharmacogenetic Covariates
Thursday 16 October, 2025
Objectives: The purpose of this study was to evaluate the effect of single nucleotide polymorphisms (SNPs) in genes involved in…
Read morePharmacokinetics and concentration-effect relationship of cetuximab in metastatic colorectal cancer
Thursday 16 October, 2025
Objectives:Â Cetuximab is a chimeric monoclonal antibody targeted against epidermal growth factor receptor (EGFR). The aim of our study was to…
Read moreModeling of longitudinal tumor size data in clinical oncology studies of drugs in combination
Thursday 16 October, 2025
Objectives: The analysis of tumor size measurements, obtained in clinical studies involving combination chemotherapy, remains an open modeling problem. We…
Read morePharmacokinetic/Pharmacodynamic Modeling of Platinum-DNA-Adduct Formation in Leukocytes after Oxaliplatin Infusion
Thursday 16 October, 2025
Objectives: The cytotoxic efficacy of platinum (Pt) complexes relies on their ability to bind to DNA, what in turn leads…
Read morePopulation pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer
Thursday 16 October, 2025
Objectives: Docetaxel has a low oral bioavailability due to affinity for P-glycoprotein and cytochrome P450 (CYP) 3A4 enzymes. Inhibition of…
Read morePharmacokinetic/Pharmacodynamic Modeling of Sunitinib in Healthy Volunteers
Thursday 16 October, 2025
Objectives: Sunitinib is a novel tyrosine kinase inhibitor approved for the treatment of advanced renal cell carcinoma and gastrointestinal stroma…
Read morePopulation Pharmacokinetics of High-dose Carboplatin
Thursday 16 October, 2025
Objectives: Carboplatin is widely used in the treatment of several malignancies. While for conventional dosing (approx. 400 mg/m²) several strategies…
Read morePopulation Pharmacokinetics of Methotrexate in Children with Lymphoid Malignancy
Thursday 16 October, 2025
Objectives: High dose methotrexate (MTX) regimen is included in the treatment protocols of lymphoid malignancy. Due to high inter and…
Read moreCombined analysis of tumor size data and histological biomarkers drives the development of a semi-mechanistic model of the effect of the antiangiogenic drug Sunitinib in mice
Thursday 16 October, 2025
Objectives: One difficulty in antiangiogenic drug development is the proper evaluation of drug efficacy. In preclinical research, biomarkers from histological…
Read more