Thursday 16 October, 2025
Introduction:ATP Binding Cassette (ABC) transporters are known to play an important role in drug absorption and distribution, normal tissue protection…
Read morePoster: Applications- Oncology
Simultaneous modelling of PSA production in Prostatic Benign Hyperplasia (PBH) and prostatic adenocarcinoma patients treated by prostate surgery
Thursday 16 October, 2025
Objectives: Prostate Specific Antigen (PSA) is mainly produces by prostate and is used as a biomarker of prostatic diseases. Prostatic…
Read morePopulation model of Human Chorionic Gonadotropin to predict resistance in low risk gestational trophoblastic neoplasia patients
Thursday 16 October, 2025
Objectives: Conventional methotrexate regimen (MTX) is recommended for treatment of patients with FIGO (International Federation of Gynecology and Obstetrics) low…
Read morePharmacokinetics of high-dose methotrexate in adults and children
Thursday 16 October, 2025
Objective: Adults and children with osteosarcoma receive high dose (12 g/m2) intravenous chemotherapy with the dihydrofolate reductase inhibitor methotrexate; daily…
Read moreHomocysteine as biomarker in a semi-mechanistic PK/PD model of methotrexate
Thursday 16 October, 2025
Objectives: Elevated homocysteine concentrations have been associated with neurotoxic symptoms upon chemotherapy with methotrexate (MTX). The aim of this study…
Read morePopulation Pharmacokinetics of Dimethylacetamide in Children During Once-daily and Standard IV Busulfan Administration
Thursday 16 October, 2025
Objectives: N,N-dimethylacetamide (DMA) is applied to children during high-dose chemoÂtherapy as a solubilizer with the intravenous (IV) formulation of busulfan…
Read moreExternal Evaluation of a Population Pharmacokinetic Model for Dosing Busulfan in Children – Body Surface Area better than Body Weight
Thursday 16 October, 2025
Objectives: A previously developed population pharmacokinetic model to evaluate the best method for dosing busulfan in children was tested by…
Read moreExternal validation of a model based on cystatin C to predict carboplatin clearance
Thursday 16 October, 2025
Objectives: The individual dosing of drugs that are mainly eliminated unchanged in the urine is made possible by assessing renal…
Read moreA semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the new PLK-1 inhibitor BI 2536 and its application in clinical development
Thursday 16 October, 2025
Background & Objectives: BI 2536 represents the first in a class of small molecules targeting and blocking activation of Polo-like kinase…
Read moreEvaluating the Influence of Different Sources of Variability in the PK/PD Tumor Growth Inhibition (TGI) Model
Thursday 16 October, 2025
Objectives: Generally, the estimate of the in vivo effect of anticancer compounds is based on the evaluation of the changes…
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