Thursday 16 October, 2025
Objectives: Administration of prokinetics with a 5-HT4 receptor agonistic property is targeted to treat GI motility disorders. Prokinetics are also…
Read morePoster: Applications- Endocrine
Disease System for osteoporosis: relating bone mineral density with measures of bone formation and resorption based on bone biology
Thursday 16 October, 2025
Objectives: Bone remodeling is regulated by a coupled action of osteoclastic and osteoblastic cells, which remove and form bone, respectively….
Read morePKPD model for cathepsin K inhibition with balicatib and changes in bone turnover biomarkers, in particular NTx
Thursday 16 October, 2025
Background: Cathepsin K is a key enzyme for the breakdown of collagen during bone resorption. Balicatib inhibits cathepsin K. The…
Read morePopulation pharmacokinetics of balicatib, a cathepsin K inhibitor
Thursday 16 October, 2025
Background: Cathepsin K is a key enzyme for the breakdown of collagen during bone resorption. Balicatib inhibits cathepsin K and…
Read morePopulation Pharmacokinetics of Rimonabant in Obesity
Thursday 16 October, 2025
Objectives: Rimonabant is an orally active selective antagonist for the cannabinoid CB1 receptor which has been developed in the treatment…
Read morePharmacokinetic modelling of the once-daily human glucagon-like peptide-1 analogue, liraglutide, in healthy volunteers and comparison to exenatide
Thursday 16 October, 2025
Objectives: Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has been shown to stimulate insulin secretion in a glucose-dependent manner,…
Read moreMechanism-based pharmacokinetic and pharmacodynamic modelling of tesaglitazar in type 2 diabetes patients
Thursday 16 October, 2025
PDF of poster Objectives: Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist in development for the treatment of…
Read moreSimultaneous population pharmacodynamic modelling of the growth hormone and insulin-like growth factor-I effects after deep subcutaneous administration of Lanreotide Autogel® in acromegalic patients. Application of Nonparametric estimation method in NONMEM
Thursday 16 October, 2025
Background: Acromegaly arises from excessive growth hormone (GH) production, which stimulates abnormally high secretion of insulin-like growth factor (IGF-I). Synthetic…
Read morePopulation Pharmacokinetic Model for Human Growth Hormone in Adult Patients in Chronic Dialysis vs. Healthy Subjects
Thursday 16 October, 2025
Objectives: To develop a population pharmacokinetics (popPK) model of human growth hormone (hGH) in patients with end-stage renal disease (ESRD)…
Read moreDelayed response to hypoglycaemic agents and effect on progression of type 2 diabetes
Thursday 16 October, 2025
Objectives: The modeling of time course of glucose and insulin changes during prolonged treatment with oral hypoglycaemic drugs has to…
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