Thursday 16 October, 2025
Objectives: The oral minimal model (OMM) coupled with a parametric model of Ra, the piecewise linear model (PLM) (1), has…
Read morePoster: Applications- Endocrine
Exposure-Response Analysis of a DPP-IV Inhibitor, PF-00734200 on HbA1c in Type 2 Diabetic Subjects on Stable Metformin Treatment
Thursday 16 October, 2025
Objectives: PF-00734200 is a dipeptidyl peptidase-IV (DPP-IV) inhibitor intended for use in the treatment of type 2 diabetes mellitus. The…
Read moreImpact of pharmacokinetic information reported as being below limit of quantification on the prediction of important response endpoints.
Thursday 16 October, 2025
Objectives: Pharmacokinetic (PK) and pharmacodynamic (PD) information are in occasions reported as being below limit of quantification (BQL). Most of…
Read moreDevelopment of a mechanistic-based pharmacodynamic model to describe the effect of a prolonged administration of a GnRH agonist on testosterone levels
Thursday 16 October, 2025
Objectives: The implementation of PD models to characterize specific processes between drug administration and its effect, are now substantially explored…
Read moreModel-Based Drug Development (MBDD) of Pegylated Growth Hormone (PEG-hGH) in the Treatment of Adult Growth Hormone Deficient (AGHD)
Thursday 16 October, 2025
Objectives: This presentation reviews the major MBDD activities and their influence on the early development of PEG-hGH and the inception…
Read moreRelationship between the Dose of Recombinant Human Growth Hormone (rhGH) and Insulin Growth Factor-1 (IGF-1) in Adult Patients with Growth Hormone Deficiency (AGHD)
Thursday 16 October, 2025
Objectives: The purpose of this meta-analysis was to characterise the relationship between rhGH dose, time, patient characteristics and IGF-1 in…
Read morePharmacokinetics of oral single-dose clomiphene citrate (CC) in polycystic ovary patient with anovulatory infertility
Thursday 16 October, 2025
Objectives: Clomiphene citrate (CC) is the first line of treatment for induction of ovulation in anovulatory infertile women with polycystic…
Read moreA physiologically based pharmacodynamic model of the Renin-Angiotensin-Aldosterone-System
Thursday 16 October, 2025
Objectives: Hypertension and blood pressure control are major cardiovascular targets to decrease morbidity and mortality in adult and paediatric patients….
Read moreAlteration of glucose and insulin regulatory networks for the treatment of type 2 diabetes mellitus
Thursday 16 October, 2025
A quantitative framework for the (patho)physiological mechanisms and pathways that underlie type 2 diabetes mellitus (T2D) was needed in order…
Read moreCovariate Selection for the IVGTT Minimal Model of Glucose Disappearance
Thursday 16 October, 2025
Objectives: Nonlinear mixed-effects modelling and its advantages have recently been discussed in the context of glucose-insulin metabolism [1,2,3] The research…
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